Human Anti-NOTCH3 scFv-Fc Chimera (VS-0425-FY161) (CAT#: VS-0425-FY161)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human NOTCH3

• Species Reactivity
• Human

• Applications
• ELISA, Flow Cytometry, Western Blot

• Related Disease
• Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1 and Lateral Meningocele Syndrome

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Notch 3; Neurogenic Locus Notch Homolog Protein 3; Notch (Drosophila) Homolog 3; Notch Homolog 3 (Drosophila); Notch Homolog 3; CADASIL1

• Gene ID
• 4854

• UniProt ID
• Q9UM47

• Long Name
• Notch 3

• Sequence Similarities
• Belongs to the NOTCH family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form.
  Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC).
  Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT).
  This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.

• Protein Refseq
• XP_005259981.1; XP_054177079.1; NP_000426.2

• Function
• Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
  Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

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