Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); scFv Fragment

Name: Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); scFv Fragment
SKU: HPAB-0282-YC-S(P)
Rating: 5 (1 reviews)

CAT#: HPAB-0282-YC-S(P)

The NOTCH signaling pathway is a universally conserved signal transduction system. It is involved in cell fate determination during development including embryonic pattern formation and post-embryonic tissue maintenance. In addition, NOTCH signaling has been identified as a critical factor in the maintenance of hematopoietic stem cells. The product is a novel antibody which binds to NOTCH3.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & actin filaments.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/if_selected.jpg

Normal Tissue Figure 2 IHC staining of human rectum

Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/ihc_selected.jpg

Normal Tissue Figure 3 IHC staining of human small intestine

Immunohistochemical staining of human small intestine shows strong nuclear and moderate cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/ihc_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_B_8_5.jpg

Normal Tissue Figure 5 Colon

Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_3.jpg

Normal Tissue Figure 6 Liver

Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_4.jpg

Normal Tissue Figure 7 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5393/15972_A_8_5.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (AF22, MCF7, RT4, U-87 MG)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000074181-NOTCH3

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Specifications

Immunogen
Recombinant human NOTCH3 protein amino acids 350-580 (NOTCH3 EGFs 9-14)

Host Species
Mouse

Type
Mouse scFv

Specificity
Human NOTCH3

Species Reactivity
Human

Clone
122M23

Applications
ELISA, IHC, WB

Related Disease
Tumor

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3

Gene ID
4854

UniProt ID
Q9UM47

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Related Diseases

Breast Cancer

Endocrine Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0282-YC-S(P).pdf

MSDS

MSDS - HPAB-0282-YC-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunohistochemistry (IHC)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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