Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); Fab Fragment
CAT#: HPAB-0282-YC-F(E)
The NOTCH signaling pathway is a universally conserved signal transduction system. It is involved in cell fate determination during development including embryonic pattern formation and post-embryonic tissue maintenance. In addition, NOTCH signaling has been identified as a critical factor in the maintenance of hematopoietic stem cells. The product is a novel antibody which binds to NOTCH3.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44392/if_selected.jpg
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Specifications
- Immunogen
- Recombinant human NOTCH3 protein amino acids 350-580 (NOTCH3 EGFs 9-14)
- Host Species
- Mouse
- Type
- Mouse Fab
- Specificity
- Human NOTCH3
- Species Reactivity
- Human
- Clone
- 122M23
- Applications
- ELISA, IHC, WB
- Related Disease
- Tumor
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Diseases
Breast Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone 122M23"
- CAT
- Product Name
See other products for "NOTCH3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1929z | Mouse Anti-NOTCH3 Recombinant Antibody (clone 22H2) | WB, ELISA | Mouse IgG2a |
| HPAB-0282-YC | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23) | ELISA, IHC, WB | Mouse IgG |
| HPAB-0283-YC | Mouse Anti-NOTCH3 Recombinant Antibody (HPAB-0283-YC) | ELISA, IHC, WB | Mouse IgG |
| HPAB-0284-YC | Mouse Anti-NOTCH3 Recombinant Antibody (HPAB-0284-YC) | ELISA, IHC, WB | Mouse IgG |
| VS3-QX826 | Mouse Anti-NOTCH3 Recombinant Antibody (clone 487CT6.9.2) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-557MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-557MZ) | Inhib, Neut | Chimeric (mouse/human) IgG1 |
| TAB-557MZ-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-557MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-557MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-557MZ-F(E)) | ELISA, WB | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-558MZ | Human Anti-NOTCH3 Recombinant Antibody (TAB-558MZ) | Inhib, Neut | Humanized IgG1 |
| TAB-558MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-558MZ-S(P)) | ELISA, WB | Humanized scFv |
| TAB-558MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-558MZ-F(E)) | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-554MZ-S(P) | Human Anti-NOTCH3 Recombinant Antibody; scFv Fragment (TAB-554MZ-S(P)) | ELISA | Human scFv |
| TAB-554MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-554MZ-F(E)) | ELISA | Human Fab |
| TAB-555MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-555MZ-F(E)) | ELISA | Human Fab |
| TAB-560MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-560MZ-F(E)) | FC | Human Fab |
| TAB-561MZ-F(E) | Human Anti-NOTCH3 Recombinant Antibody; Fab Fragment (TAB-561MZ-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0282-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody (clone 122M23); scFv Fragment | ELISA, IHC, WB | Mouse scFv |
| HPAB-0283-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-0283-YC-S(P)) | ELISA, IHC, WB | Mouse scFv |
| HPAB-0284-YC-S(P) | Mouse Anti-NOTCH3 Recombinant Antibody; scFv Fragment (HPAB-0284-YC-S(P)) | ELISA, IHC, WB | Mouse scFv |
| HPAB-1010WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12); scFv Fragment | ELISA, WB, FC | Human scFv |
| HPAB-1011WJ-S(P) | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160); scFv Fragment | ELISA, WB, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0283-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-0284-YC-F(E) | Mouse Anti-NOTCH3 Recombinant Antibody; Fab Fragment (HPAB-0284-YC-F(E)) | ELISA, IHC, WB | Mouse Fab |
| HPAB-0754-WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone N37); Fab Fragment | ELISA | Human Fab |
| HPAB-1010WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone N3WCR3P1B12); Fab Fragment | ELISA, WB, FC | Human Fab |
| HPAB-1011WJ-F(E) | Human Anti-NOTCH3 Recombinant Antibody (clone hN3S2_160); Fab Fragment | ELISA, WB, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC81 | Rabbit Anti-NOTCH3 Antibody (VS-0924-YC81) - Cancer Stem Cell Marker | IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY161 | Human Anti-NOTCH3 scFv-Fc Chimera (VS-0425-FY161) | ELISA, FC, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC122 | Recombinant Anti-NOTCH3 Vesicular Antibody, EV Displayed (VS-0425-YC122) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4910 | Anti-NOTCH3 Immunohistochemistry Kit | IHC |
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