Anti-MSLN (clone h7D9.v3)-mc-MMAF ADC
CAT#: ADC-225LZY
This ADC product is composed of an anti-MSLN antibody (clone h7D9v3 ) conjugated via mc linker to MMAF (h7D9v3-mc-MMAF). It has demonstrated a response in epithelial cancers treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/17172/1276_A4_4_selected.jpg
Normal Tissue
Figure 2 Fallopian tube
Ciliated cells (cilia axoneme)
Staining:
High
Intensity: Strong
Ciliated cells (tip of cilia)
Staining:
High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2216/6076_A_7_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, HeLa, hTCEpi, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102854-MSLN
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Specifications
- Antibody Overview
- Humanized Anti-MSLN mAb,h7D9.v3
- Clone
- h7D9v3
- Linker
- mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- MMAF (monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
- Alternative Names
- MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor;
- Gene ID
- 10232
- UniProt ID
- Q13421
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Datasheet
MSDS
COA
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See other products for "Clone h7D9v3"
- CAT
- Product Name
See other products for "MSLN"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-009 | Recombinant Anti-human MSLN VHH Single Domain Antibody | WB, IHC, FC, FuncS | Llama VHH |
| HPAB-M0391-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0391-YC) | ELISA, FC, IF | Llama VHH |
| HPAB-M0392-YC | Recombinant Llama Anti-MSLN Single Domain Antibody (HPAB-M0392-YC) | ELISA, FC, IF | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-201 | Anti-Human Mesothelin Recombinant Antibody (TAB-201) | IP, IF, FuncS, FC, Neut, ELISA, IHC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G052E | Anti-MSLN immunotoxin RG7787 (Fab)-PE | Cytotoxicity assay, Function study | |
| AGTO-G053E | Anti-Msln immunotoxin (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-L035E | anti-MSLN immunotoxin K1 (IgG)-PE | Cytotoxicity assay, Functional assay | |
| AGTO-L063E | anti-MSLN immunotoxin 8B35 (scFv)-PE | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0833CL | Human Anti-MSLN Recombinant Antibody (TAB-0833CL) | ELISA, FuncS, Activ, FC | Human IgG1 |
| TAB-0834CL | Human Anti-MSLN Recombinant Antibody (TAB-0834CL) | ELISA, FuncS, FC, SPR, Inhib | Human IgG1, κ |
| TAB-0833CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0833CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0834CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0834CL-S(P)) | ELISA, FC | Human scFv |
| TAB-0835CL-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (TAB-0835CL-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0376MZ | Chicken Anti-MSLN Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2302 | Hi-Affi™ Recombinant Rabbit Anti-MSLN Monoclonal Antibody (DS2302AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0041-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0041-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0042-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0042-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0043-CN-F(E) | Mouse Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0043-CN-F(E)) | FC, WB, ELISA | Mouse Fab |
| HPAB-0044-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0044-CN-F(E)) | FC, WB, ELISA | Human Fab |
| HPAB-0045-CN-F(E) | Human Anti-MSLN Recombinant Antibody; Fab Fragment (HPAB-0045-CN-F(E)) | FC, WB, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0442LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0442LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| HPAB-0443LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0443LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| HPAB-0444LY-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-0444LY-S(P)) | ELISA, FC, IHC, WB | Human scfv |
| HPAB-M0155-YC-S(P) | Human Anti-MSLN Recombinant Antibody (clone M/YC-16); scFv Fragment | ELISA, WB | Mouse scFv |
| HPAB-M0157-YC-S(P) | Human Anti-MSLN Recombinant Antibody; scFv Fragment (HPAB-M0157-YC-S(P)) | FuncS | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-201 | Afuco™ Anti-MSLN ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-201) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0257WJ | Human Anti-MSLN Recombinant Antibody (clone H1a050) | ELISA, WB, FC | Human IgG |
| FAMAB-0258WJ | Human Anti-MSLN Recombinant Antibody (FAMAB-0258WJ) | ELISA, WB, FC | Human IgG |
| FAMAB-0259WJ | Human Anti-MSLN Recombinant Antibody (FAMAB-0259WJ) | ELISA, WB, FC | Human IgG |
| FAMAB-0260WJ | Human Anti-MSLN Recombinant Antibody (FAMAB-0260WJ) | ELISA, WB, FC | Human IgG |
| FAMAB-0261WJ | Human Anti-MSLN Recombinant Antibody (FAMAB-0261WJ) | ELISA, WB, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY69 | Human Anti-MSLN (clone SS) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC539 | Recombinant Anti-MSLN Vesicular Antibody, EV Displayed (VS-0425-YC539) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4533 | Anti-MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4534 | Anti-Mouse MSLN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4535 | Anti-Rat MSLN Immunohistochemistry Kit | IHC |
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