Recombinant Human Anti-MDM2 Soluble TCR (1bd2) (KIH)
CAT#: VS-0622-YF5621
Human TCR (1bd2) recognizes MDM2 peptide (aa 81-88) in the context of HLA-A2.1. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/1999_F7_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong nuclear positivity.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/37938_A_6_7_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/170698_A_2_7_selected.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_3.jpg
Normal Tissue
Figure 8 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_4.jpg
Normal Tissue
Figure 9 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Pancreatic endocrine cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_2_3.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_5.jpg
Normal Tissue
Figure 11 Testis
Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Peritubular cells
Staining: High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_5_6.jpg
Normal Tissue
Figure 12 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_8.jpg
RNA Expression
Figure 13 RNA cell line category: Cell line enhanced (HBEC3-KT, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135679-MDM2
❮
❯
Specifications
- Host Species
- Human
- Target
- MDM2
- Species Reactivity
- Human
- Epitope
- aa 81-88
- MHC
- HLA-A2.1
- Clone
- 1bd2
- Type
- Soluble TCR (KIH)
- Related Disease
- Cancer
- TCR Expression Strategy
- KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0622-YF5621. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Bladder Cancer
EGFR Tyrosine Kinase Inhibitor Resistance
Gastric Cancer
Prostate Cancer
Related Signaling Pathways
p53 Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 1bd2"
- CAT
- Product Name
See other products for "MDM2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-648 | Recombinant Anti-human MDM2 Antibody | ELISA, WB, IF, FuncS | IgG |
| MOB-1012CT | Recombinant Mouse anti-Human MDM2 Monoclonal antibody (3H3) | WB | |
| VS3-XY1056 | Mouse Anti-MDM2 Recombinant Antibody (clone 3G2) | WB, IP, IF, IHC | Mouse IgG1 |
| VS3-WK838 | Mouse Anti-MDM2 Recombinant Antibody (VS3-WK838) | WB | Mouse IgG |
| VS3-WK2255 | Rabbit Anti-MDM2 (pS166) Recombinant Antibody (VS3-WK2255) | WB, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-648-F(E) | Recombinant Anti-human MDM2 Antibody Fab Fragment | WB, FACS, FuncS | Fab |
| MHH-648-F(E) | Recombinant Human Anti-human MDM2 Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-648-S(P) | Recombinant Anti-human MDM2 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-648-S(P) | Recombinant Human Anti-human MDM2 Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0353MZ | Chicken Anti-MDM2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4642 | Hi-Affi™ Recombinant Rabbit Anti-MDM2 Monoclonal Antibody (TH155DS) | WB, IF, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1420 | PE-A*02:01/Human MDM2 (LLGDLFGV) MHC Tetramer | FCM | |
| MHC-YF287 | A*02:01/Human MDM2 (LLGDLFGV) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4322 | Anti-MDM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4323 | Anti-Human MDM2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-FY8 | Mouse Anti-MDM2 scFv-Fc Chimera (VS-0625-FY8) | ELISA, WB | Mouse IgG1, scFv-Fc |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
-YJ-3.jpg)
Application: ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, FC, Neut, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
