Human Anti-SIRPA (clone 29-AM3-35) scFv-Fc Chimera (CAT#: VS-0325-FY86)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• 29-AM3-35 specifically binds to the two most common variants of the human SIRPα IgV domain (V1 and V2).

• Species Reactivity
• Human

• Clone
• 29-AM3-35

• Applications
• ELISA, Inhibition

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Signal Regulatory Protein Alpha; CD172 Antigen-Like Family Member A; Inhibitory Receptor SHPS-1; Macrophage Fusion Receptor; PTPNS1; SHPS1; SIRP; P84; BIT; MFR; Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs; Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs; Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1; Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1; Tyrosine Phosphatase SHP Substrate 1; Signal-Regulatory Protein Alpha-1

• Gene ID
• 140885

• UniProt ID
• P78324

• Long Name
• Signal Regulatory Protein Alpha

• Cellular Localization
• Membrane

• Post Translation Modifications
• N-glycosylated.
  Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF.
  Dephosphorylated by PTPN11.
  Glycosylation at Asn110, Asn245, Asn270, Asn292, and Asn319
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect SHPS1_HUMAN (650)
  Glycosylation from GlyGen 10 sites, 14 N-linked glycans (4 sites), 1 O-linked glycan (3 sites)

• Protein Refseq
• XP_005260727.1; XP_011527475.1; XP_024307604.1; XP_047295871.1; XP_047295872.1

• Function
• Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.
  Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment.
  May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity).
  Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

• NS-080CN
• Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35)

• NS-080CN-F(E)
• Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35); Fab Fragment

• NS-080CN-S(P)
• Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35); scFv Fragment

Select a product category from the dropdown menu below to view related products.