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    Rabbit Anti-SYK (clone MIL81-1-8) scFv-Fc Chimera (CAT#: VS-0425-FY47)

    The anti-SYK scFv-Fc fusion protein targets Spleen tyrosine kinase (SYK), a key enzyme in immune signaling. This engineered protein combines a single-chain variable fragment (scFv) for specific SYK binding with an Fc domain to enhance stability and effector functions. Its primary mechanism involves inhibiting SYK activity, thereby disrupting downstream signaling pathways involved in inflammation and autoimmune responses. This disruption can mitigate conditions like rheumatoid arthritis and allergic reactions. The Fc portion extends the protein's half-life, improving its therapeutic potential.

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    • Purity:

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    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line HEK 293
    Figure 1 IF staining of human cell line HEK 293
    (Immunofluorescent staining of human cell line HEK 293 shows localization to plasma membrane & cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/1384/1472_A1_6_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glial cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Glandular cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Cholangiocytes
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Collecting ducts
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Distal tubules
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Sertoli cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_6_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_7_8.jpg
    Figure 8 Tonsil
    Figure 8 Tonsil
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Squamous epithelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/7773/18512_A_6_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, HMC-1, REH, THP-1, U-698, U-937)
    Figure 9 RNA cell line category: Cell line enhanced (Daudi, HEL, HL-60, HMC-1, REH, THP-1, U-698, U-937)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165025-SYK/subcellular

    Specifications

    • Immunogen
    • The immunogen used to generate the MIL81-1-8 antibody was a synthetic phosphopeptide corresponding to residues surrounding Tyr525/526 of human SYK.
    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG, scFv-Fc
    • Specificity
    • The MIL81-1-8 clone is reactive to phosphorylated SYK (pSYK), specifically at tyrosine residues 525 and 526 (pSYK Y525/526).
    • Species Reactivity
    • Human
    • Clone
    • MIL81-1-8
    • Applications
    • Immunohistochemistry
    • Related Disease
    • Autoimmune disease, Alzheimer's disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Immunohistochemistry: 3.5 μg/mL
      The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • IMD82; p72-Syk
    • Long Name
    • Spleen Associated Tyrosine Kinase
    • Sequence Similarities
    • Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
    • Cellular Localization
    • Cell membrane, Cytoplasm
    • Post Translation Modifications
    • Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.
      Autophosphorylated.
      Ubiquitination at Lys517
      Modification sites at PhosphoSitePlus
      Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
    • Function
    • Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR).
      Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development.
      Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains.

    Related Resources

    • Related Signaling Pathways

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "SYK"

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    Fab Antibody Products ScFv Antibody Products Rabbit Monoclonal Antibody Products IgG Antibody Products
    CAT Product Name Application Type
    MOB-937-F(E) Recombinant Anti-human SYK Antibody Fab Fragment IF, FACS, FuncS Fab
    MHH-937-F(E) Recombinant Human Anti-human SYK Antibody Fab Fragment FC, ELISA, FuncS Fab
    HPAB-0225-YC-F(E) Rabbit Anti-SYK Recombinant Antibody; Fab Fragment (HPAB-0225-YC-F(E)) IHC, FuncS Rabbit Fab

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