Recombinant Mouse Anti-ENG Antibody (clone 6A6-5B7-8G9) (CAT#: VS3-FY497)
This product is a recombinant mouse antibody that recognizes human ENG protein. The mAb was purified by affinity chromatography.
Specific Inquiry
IHC
Figure 1. Recombinant Mouse Anti-ENG Antibody (clone 6A6-5B7-8G9) in IHC.
Immunohistochemical analysis of paraffin-embedded Kindey using CD105 antibody. High pressure and high temperature sodium citrate pH 6.0 for antigen retrieval.
Specifications
- Immunogen
- Synthesized peptide derived from human CD105(Endoglin)
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human ENG
- Species Reactivity
- Human
- Clone
- 6A6-5B7-8G9
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography Purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS pH 7.3, 50% Glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/100-1/500
Target
- Alternative Names
- Endoglin; CD105 Antigen; END; Osler-Rendu-Weber Syndrome 1; HHT1; ORW1
- Gene ID
- 2022
- UniProt ID
- P17813
- Cellular Localization
- Cell membrane, Membrane
- Protein Refseq
- NP_000109.1; NP_001108225.1; NP_001265067.1
- Function
- Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).
Required for normal structure and integrity of adult vasculature (PubMed:7894484).
Regulates the migration of vascular endothelial cells (PubMed:17540773).
Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).
May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).
May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).
Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1309z | Mouse Anti-ENG Recombinant Antibody (clone 27H2) | IF, IHC, WB | Mouse IgG1 |
| HPAB-0713-CN | Human Anti-ENG Recombinant Antibody (clone 6B10) | WB, FC | Human IgG |
| HPAB-0714-CN | Human Anti-ENG Recombinant Antibody (clone 4.120) | WB, FC | Human IgG |
| HPAB-0715-CN | Human Anti-ENG Recombinant Antibody (clone 4.37) | WB, FC | Human IgG |
| HPAB-0137-WJ | Human Anti-ENG Recombinant Antibody (HPAB-0137-WJ) | ELISA | Humanized IgG4, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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