Recombinant Anti-IL1RAP Vesicular Antibody, EV Displayed (VS-0425-YC206)
CAT#: VS-0425-YC206
The Recombinant Anti-IL1RAP Vesicular Antibody, EV Displayed (VS-0425-YC206) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL1RAP-expressed cells or tissues. The IL1RAP is an accessory protein forming part of the interleukin 1 receptor complex, activating interleukin 1-responsive genes. The soluble to membrane-bound form ratio increases during stress.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196083-IL1RAP
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL1RAP
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 1 receptor accessory protein
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Hydrolase, Receptor
- Cellular Localization
- Vesicles, Cytosol
- Introduction
- Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
- Alternative Names
- C3orf13, IL-1RAcP, IL1R3
- Gene ID
- 3556
- UniProt ID
- Q9NPH3
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Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-559-F(E) | Recombinant Anti-human IL1RAP Antibody Fab Fragment | IF, ELISA, FuncS | Fab |
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| HPAB-M0110-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0110-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-M0111-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0111-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-559-S(P) | Recombinant Anti-human IL1RAP Antibody scFv Fragment | FC, IP, FuncS | scFv |
| MHH-559-S(P) | Recombinant Human Anti-human IL1RAP Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| HPAB-M0109-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0109-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0110-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0110-YC-S(P)) | ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0380CL-F(E) | Anti-Human IL1RAP Recombinant Antibody Fab Fragment (1F5) | ELISA, FC | |
| TAB-0381CL-F(E) | Anti-Human IL1RAP Recombinant Antibody Fab Fragment | ELISA, FC, FuncS | |
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| TAB-221CT-F(E) | Mouse Anti-IL1RAP Recombinant Antibody; Fab Fragment (TAB-221CT-F(E)) | FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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