Recombinant Anti-IL1RAP Vesicular Antibody, EV Displayed (VS-0425-YC206)
CAT#: VS-0425-YC206
The Recombinant Anti-IL1RAP Vesicular Antibody, EV Displayed (VS-0425-YC206) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to IL1RAP-expressed cells or tissues. The IL1RAP is an accessory protein forming part of the interleukin 1 receptor complex, activating interleukin 1-responsive genes. The soluble to membrane-bound form ratio increases during stress.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- IL1RAP
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Interleukin 1 receptor accessory protein
- Biological Process
- Immunity, Inflammatory response, Innate immunity
- Molecular Function
- Hydrolase, Receptor
- Cellular Localization
- Vesicles, Cytosol
- Introduction
- Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. [provided by RefSeq, Nov 2009]
- Alternative Names
- C3orf13, IL-1RAcP, IL1R3
- Gene ID
- 3556
- UniProt ID
- Q9NPH3
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Related Diseases
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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