Anti-Human IL1RAP Recombinant Antibody (4B6)
CAT#: TAB-0382CL
The anti-IL1RAP antibody specifically bind to the membrane-bound form of IL1RAP, which is a co-receptor for IL1 that function in the IL1 receptor signal transduction complex and is also expressed on cancer cells and caner stem cells. The specific antibody can be used in the treatment of hematopoietic cell cancers such as acute myeloid leukemia (AML), chronic myeloid leukemia (CML) and chronic myelomoncytic leukemia (CMML).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196083-IL1RAP
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Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 4B6
- Related Disease
- Acute myeloid leukemia (AML), chronic myeloid leukemia (CML), chronic myelomoncytic leukemia (CMML)
Target
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Related Diseases
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone 4B6"
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See other products for "IL1RAP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0380CL-S(P) | Anti-Human IL1RAP Recombinant Antibody scFv Fragment (1F5) | ELISA, FC | |
| TAB-0381CL-S(P) | Anti-Human IL1RAP Recombinant Antibody scFv Fragment | ELISA, FC, FuncS | |
| TAB-0382CL-S(P) | Anti-Human IL1RAP Recombinant Antibody scFv Fragment (4B6) | ELISA, FC | |
| TAB-0380CL-F(E) | Anti-Human IL1RAP Recombinant Antibody Fab Fragment (1F5) | ELISA, FC | |
| TAB-221CT-F(E) | Mouse Anti-IL1RAP Recombinant Antibody; Fab Fragment (TAB-221CT-F(E)) | FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0109-YC | Human Anti-IL1RAP Recombinant Antibody (HPAB-M0109-YC) | ELISA | Humanized IgG |
| HPAB-M0110-YC | Human Anti-IL1RAP Recombinant Antibody (HPAB-M0110-YC) | ELISA | Humanized IgG |
| HPAB-M0111-YC | Human Anti-IL1RAP Recombinant Antibody (HPAB-M0111-YC) | ELISA | Humanized IgG |
| HPAB-M0112-YC | Human Anti-IL1RAP Recombinant Antibody (HPAB-M0112-YC) | ELISA | Humanized IgG |
| HPAB-M0113-YC | Human Anti-IL1RAP Recombinant Antibody (HPAB-M0113-YC) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0109-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0109-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0110-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0110-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0111-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0111-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0112-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0112-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0113-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0113-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0112-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0112-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-M0113-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0113-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-M0114-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0114-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-M0115-YC-F(E) | Human Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-M0115-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-0466-FY-F(E) | Mouse Anti-IL1RAP Recombinant Antibody; Fab Fragment (HPAB-0466-FY-F(E)) | Inhib, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC46 | Rabbit Anti-IL1RAP Antibody (VS-0924-YC46) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY109 | Mouse Anti-IL1RAP (clone 4B6) scFv-Fc Chimera | ELISA, FC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC206 | Recombinant Anti-IL1RAP Vesicular Antibody, EV Displayed (VS-0425-YC206) | ELISA, FC, Cell-uptake |
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