Rabbit Anti-IL1RAP Antibody (VS-0924-YC46) - Cancer Stem Cell Marker
CAT#: VS-0924-YC46
This product is an anti-IL1RAP antibody (VS-0924-YC46) designed to target the human IL1RAP protein, a marker of cancer stem cells (CSCs). It is suitable for IL1RAP detection in CSC tissues or cells using Immunohistochemistry at a dilution of 1/50 to 1/200.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_9_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enriched (SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196083-IL1RAP
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human IL1RAP
- Species Reactivity
- Human
- Applications
- IHC
- Related Disease
- Autoinflammatory diseases
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified using the PrEST antigen as affinity ligand
- Concentration
- 0.1 mg/mL
- Buffer
- PBS, pH 7.2, with 40% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/50-1/200
Target
- Alternative Names
- C3orf13; IL-1RAcP; IL1R3
- Gene ID
- 3556
- UniProt ID
- Q9NPH3
- Long Name
- Interleukin 1 receptor accessory protein
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn57, Asn107, Asn111, Asn118, Asn196, Asn209, and Asn299 (NX_Q9NPH3 [NX_Q9NPH3-1])
Modification sites at PhosphoSitePlus (Q9NPH3)
Glycosylation from GlyConnect IL1AP_HUMAN (1425)
Glycosylation from GlyGen (Q9NPH3) 9 sites, 13 N-linked glycans (3 sites)
- Protein Refseq
- XP_016861837.1; XP_047304037.1; XP_047304038.1; XP_047304039.1; XP_047304040.1
- Function
- The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).
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Related Diseases
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Downloadable Resources
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Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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