Mouse Anti-IL1RAP (clone 4B6) scFv-Fc Chimera (CAT#: VS-0325-FY109)
The anti-IL1RAP scFv-Fc antibody targets IL-1R accessory protein (IL1RAP), a key component in IL-1 signaling pathways. It is formulated with a scFv-Fc construct to improve binding affinity and functional versatility. This antibody is useful for studying IL-1 signaling and its role in inflammatory and autoimmune diseases.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/372_B3_2_selected.jpg
Figure 2 IHC staining of human lymph node
(Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/ihc_selected.jpg
(Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_B_7_5.jpg
(Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_B_7_5.jpg
Figure 4 Colon
(Peripheral nerve/ganglion
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_9_3.jpg
(Peripheral nerve/ganglion
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_7_5.jpg
(Cells in tubules
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_7_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/35293/79779_A_6_6.jpg
Figure 7 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196083-IL1RAP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196083-IL1RAP
Specifications
- Immunogen
- The extracellular region of human IL1RAP.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human IL1RAP
- Species Reactivity
- Human
- Clone
- 4B6
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Acute myeloid leukemia (AML)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 1 Receptor Accessory Protein
- Gene ID
- 3556
- UniProt ID
- Q9NPH3
- Long Name
- Interleukin 1 Receptor Accessory Protein
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn57, Asn107, Asn111, Asn118, Asn196, Asn209, and Asn299
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IL1AP_HUMAN (1425)
Glycosylation from GlyGen 9 sites, 13 N-linked glycans (3 sites)
- Protein Refseq
- XP_016861837.1; XP_047304037.1; XP_047304038.1; XP_047304039.1; XP_047304040.1
- Function
- The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity).
May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).
Recommended Products
Secondary Antibody
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-559-S(P) | Recombinant Human Anti-human IL1RAP Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| HPAB-M0109-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0109-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0110-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0110-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0111-YC-S(P) | Human Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-M0111-YC-S(P)) | ELISA | Human scFv |
| HPAB-0466-FY-S(P) | Mouse Anti-IL1RAP Recombinant Antibody; scFv Fragment (HPAB-0466-FY-S(P)) | Inhib, FC | Mouse scFv |
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