Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479)

Name: Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479)
SKU: VS-0425-YC479
Rating: 5 (1 reviews)

CAT#: VS-0425-YC479

The Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MET-expressed cells or tissues. The MET is a receptor tyrosine kinase linked to cancer, with mutations associated with several cancer types.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

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Recombinant Antibody

Application
ELISA, FC, Neut, Cell-uptake

Product Type
Ab-Fc-EVs

Antibody Quantification (Ab/EV)
~100 Ab/EV

Target
MET

Host Animal
Human

Antibody Isotype
IgG

Species Reactivity
Human

Expression Cell
Mammalian cell

Engineered EVs

EV-sorting domain
CD63

Fc-binding domain
z domain

EV Size
30~150 nm

Producing Cell
HEK293F

Isolation Method
Gradient centrifugation

Purification
qEV size exclusion chromatography

Binding Affinity
Kd = 0.85 µg/mL

Concentration
1 x 10¹⁰

Size
1 mL

Buffer
PBS

Storage
Store at -80°C for 12 months

Target

Full Name
MET proto-oncogene, receptor tyrosine kinase

Molecular Function
Kinase, Receptor, Transferase, Tyrosine-protein kinase

Cellular Localization
Plasma membrane, Cytosol

Introduction
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Alternative Names
DFNB97, HGFR, RCCP2

Gene ID
4233

UniProt ID
P08581

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

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Datasheet

Datasheet - VS-0425-YC479.pdf

MSDS

MSDS - VS-0425-YC479.pdf

COA

Certificate of Analysis Lookup

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