Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479)
CAT#: VS-0425-YC479
The Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to MET-expressed cells or tissues. The MET is a receptor tyrosine kinase linked to cancer, with mutations associated with several cancer types.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- MET
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- MET proto-oncogene, receptor tyrosine kinase
- Molecular Function
- Kinase, Receptor, Transferase, Tyrosine-protein kinase
- Cellular Localization
- Plasma membrane, Cytosol
- Introduction
- This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
- Alternative Names
- DFNB97, HGFR, RCCP2
- Gene ID
- 4233
- UniProt ID
- P08581
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "MET"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-521CL | Anti-Human MET Recombinant Antibody (TAB-521CL) | WB, FuncS | Antibody |
| TAB-0881CLV | Human Anti-MET Recombinant Antibody (TAB-0881CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0883CLV | Human Anti-MET Recombinant Antibody (TAB-0883CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0884CLV | Human Anti-MET Recombinant Antibody (TAB-0884CLV) | ELISA, FuncS | Humanized IgG1 |
| TAB-0885CLV | Human Anti-MET Recombinant Antibody (TAB-0885CLV) | ELISA, FuncS | Humanized IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155) | ELISA, Neut | ADCC enhanced antibody |
| AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-155 | Humanized Anti-MET Recombinant Antibody Fab Fragment (PFBZ-155) | ELISA, Neut | Human Fab |
| HPAB-0071-YC-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0071-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0072-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0072-YC-S(P)) | ELISA | Humanized scFv |
| HPAB-0073-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0073-YC-S(P)) | ELISA | Human scFv |
| HPAB-0077-YC-S(P) | Mouse Anti-MET Recombinant Antibody (clone LMH 89); scFv Fragment | ELISA, FC, Stim, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534LC | Mouse Anti-MET Recombinant Antibody (TAB-534LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-535LC | Mouse Anti-MET Recombinant Antibody (TAB-535LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-001MZ | Anti-Human MET Recombinant Antibody (DN30) | IHC, PET imaging | |
| TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
| TAB-012MZ | Mouse Anti-MET Recombinant Antibody (TAB-012MZ) | ELISA, WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-536LC | Human Anti-MET Recombinant Antibody (TAB-536LC) | Inhib | Human IgG2 |
| TAB-537LC | Human Anti-MET Recombinant Antibody (TAB-537LC) | Inhib | Human IgG2 |
| TAB-538LC | Human Anti-MET Recombinant Antibody (TAB-538LC) | Inhib | Human IgG2 |
| TAB-539LC | Human Anti-MET Recombinant Antibody (TAB-539LC) | Inhib | Human IgG2 |
| TAB-540LC | Human Anti-MET Recombinant Antibody (TAB-540LC) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002MZ | Anti-Human MET Recombinant Antibody (TAB-002MZ) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| TAB-0880CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC, IF, IHC-P, WB | IgG |
| MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
| MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
| MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-WJ-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0030-WJ-F(E)) | ELISA, WB | Human Fab |
| HPAB-AP146-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-AP146-YC-F(E)) | FC, IHC | Mouse Fab |
| HPAB-AP147-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-AP147-YC-F(E)) | FC, IHC | Mouse Fab |
| HPAB-N0176-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-N0176-YC-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-1579-FY-S(P) | Human Anti-MET Recombinant Antibody scFv Fragment (HPAB-1579-FY-S(P)) | WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1298LY | Human Anti-MET Recombinant Antibody (HPAB-1298LY) | ELISA, IP | Human IgG2 |
| HPAB-1299LY | Human Anti-MET Recombinant Antibody (HPAB-1299LY) | ELISA, IP | Human IgG2 |
| HPAB-1300LY | Human Anti-MET Recombinant Antibody (HPAB-1300LY) | ELISA, IP | Human IgG2 |
| HPAB-1301LY | Human Anti-MET Recombinant Antibody (HPAB-1301LY) | ELISA, IP | Human IgG2 |
| HPAB-1302LY | Human Anti-MET Recombinant Antibody (HPAB-1302LY) | ELISA, IP | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF474 | A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY131 | Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5) | WB, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY58 | Human Anti-Met (clone 5D5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1336 | Anti-MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4357 | Anti-Mouse MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4356 | Anti-Human MET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC10 | Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA | Asymmetric hetero HC, common LC |
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