Anti-MET Antibody Prodrug, Protease Activated (VS-1025-YC26)
CAT#: VS-1025-YC26
The Anti-MET Antibody Prodrug, Protease Activated (VS-1025-YC26) is an antibody prodrug comprised of a recombinant mouse antibody targeting human MET, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MET protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MET effectively. MET (Mesenchymal-Epithelial Transition factor) is a receptor tyrosine kinase and potent oncogene activated by gene amplification, exon 14 skipping mutations, or overexpression. These alterations are found in various cancers, including lung, gastric, and renal cell carcinoma, promoting cell motility, invasion, and metastasis (the "scatter factor" effect). MET inhibitors target this hyperactive receptor to block tumor progression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MET
- Target
- MET
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
- Alternative Names
- HGFR; AUTS9; RCCP2; c-Met; DFNB97
- Gene ID
- 4233
- UniProt ID
- P08581
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
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Datasheet
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COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H24 | Anti-Human MET Recombinant Antibody (TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG4 - kappa |
| TAB-190-F(E) | Anti-Human Met(Onartuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Fab / Fc - G1 - kappa |
| TAB-521CL | Anti-Human MET Recombinant Antibody (TAB-521CL) | WB, FuncS | Antibody |
| TAB-0332CL | Human Anti-MET Recombinant Antibody (TAB-0332CL) | ELISA | Humanized Antibody |
| TAB-0332CL-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-271 | Human Anti-MET Recombinant Antibody (PABL-271) | WB, Block, FuncS | Human IgG |
| MOB-1226CT | Recombinant Mouse anti-Human MET Monoclonal antibody (9G22) | IHC-Fr, IHC-P | |
| HPAB-0071-YC | Mouse Anti-MET Recombinant Antibody (HPAB-0071-YC) | ELISA, Inhib | Mouse IgG |
| HPAB-0072-YC | Human Anti-MET Recombinant Antibody (HPAB-0072-YC) | ELISA | Humanized IgG1, κ |
| HPAB-0073-YC | Human Anti-MET Recombinant Antibody (HPAB-0073-YC) | ELISA | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-271 | Human Anti-MET Recombinant Antibody scFv Fragment (PSBL-271) | WB, Block, FuncS | Human scFv |
| PFBZ-155 | Humanized Anti-MET Recombinant Antibody Fab Fragment (PFBZ-155) | ELISA, Neut | Human Fab |
| HPAB-0071-YC-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0071-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0072-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0072-YC-S(P)) | ELISA | Humanized scFv |
| HPAB-0073-YC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0073-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-271 | Human Anti-MET Recombinant Antibody Fab Fragment (PFBL-271) | WB, Block, FuncS | Human Fab |
| PSBZ-155 | Humanized Anti-MET Recombinant Antibody scFv Fragment (PSBZ-155) | ELISA, Neut | Human scFv |
| HPAB-0071-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0071-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0072-YC-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0072-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-0073-YC-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0073-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155) | ELISA, Neut | ADCC enhanced antibody |
| AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0530CL | Anti-Human MET Recombinant Antibody | ELISA, FC, IF, FuncS | |
| TAB-0530CL-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment | ELISA, FC, IF, FuncS | |
| TAB-0530CL-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment | ELISA, FC, IF, FuncS | |
| TAB-536LC | Human Anti-MET Recombinant Antibody (TAB-536LC) | Inhib | Human IgG2 |
| TAB-537LC | Human Anti-MET Recombinant Antibody (TAB-537LC) | Inhib | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534LC | Mouse Anti-MET Recombinant Antibody (TAB-534LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-535LC | Mouse Anti-MET Recombinant Antibody (TAB-535LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-001MZ | Anti-Human MET Recombinant Antibody (DN30) | IHC, PET imaging | |
| TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
| TAB-012MZ | Mouse Anti-MET Recombinant Antibody (TAB-012MZ) | ELISA, WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002MZ | Anti-Human MET Recombinant Antibody (TAB-002MZ) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| TAB-0880CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC, IF, IHC-P, WB | IgG |
| MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
| MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
| MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY131 | Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5) | WB, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY58 | Human Anti-Met (clone 5D5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1336 | Anti-MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4357 | Anti-Mouse MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4356 | Anti-Human MET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC479 | Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC10 | Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA | Asymmetric hetero HC, common LC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC251 | SmartAb™ Recombinant Anti-MET pH-dependent Antibody (VS-0825-YC251) | IF, Neut, ELISA, FC, IP, WB | Human IgG4 kappa |
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