Met

Creative Biolabs offers advanced recombinant antibodies specifically designed to target MET, catering to the needs of biomedical researchers. We strive to support scientific progress by providing high-quality recombinant products known for their superior performance. Alongside exceptional value, we offer comprehensive technical support to help researchers achieve optimal outcomes. By utilizing our MET antibodies, you equip your studies with reliable tools that drive impactful discoveries and further advancements in biomedical science.

MET: A Crucial target in Cancer and Tumor growth

MET (mesenchymal-epithelial transition factor) is a receptor tyrosine kinase that plays a critical role in various cellular processes, including growth, survival, and differentiation. Activated by its ligand, hepatocyte growth factor (HGF), MET signaling regulates embryonic development, tissue regeneration, and wound healing. Aberrant MET expression or activation is associated with multiple cancers, contributing to tumor growth, metastasis, and resistance to therapies. Due to its pivotal role in oncogenesis, MET has emerged as a valuable therapeutic target, with ongoing research focusing on understanding its mechanisms and developing targeted therapies to inhibit its dysregulated activity in diseases.

Alternative Names

DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97

Background

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Anti-MET rAb Products

We offer premium anti-MET recombinant antibody products designed to support and advance biological research efforts, facilitating the exploration and discovery of the MET target with exceptional reliability.

Creative Quality Control

To meet customer expectations, we have implemented a rigorous quality management system that ensures the excellence of our products while providing reliable and professional technical support, empowering researchers with the tools needed to achieve their scientific goals.

Customer Reviews

Excellent

Ca**y
Anti-Human MET Recombinant Antibody (ABT-700) (Cat#: TAB-521CL)

The Anti-Human MET Recombinant Antibody (ABT-700) proved highly effective in my research, where I used it for Western blot and functional assays. It displayed outstanding specificity, accurately identifying MET expression in cell lysates. Moreover, its ability to inhibit MET activity in functional assays highlighted its reliability for exploring MET-related signaling mechanisms, making it indispensable for my study.

13/Dec/2022

Excellent

O**v*a
Human Anti-MET Recombinant Antibody (clone 5D5) (Cat#: PABL-271)

I used the Human Anti-MET Recombinant Antibody (clone 5D5) in my research for Western blotting and blocking assays. It delivered precise and consistent detection of MET expression and effectively blocked MET signaling pathways. These results provided critical insights into MET's role in cell signaling, significantly advancing my understanding of its biological functions.

9/Jul/2023

Excellent

Da**el
Human Anti-MET Recombinant Antibody (Cat#: TAB-009MZ)

In my study, the Human Anti-MET Recombinant Antibody played a pivotal role in detecting MET expression. Using ELISA and flow cytometry, the antibody showcased exceptional sensitivity and accuracy, delivering reliable data on MET-positive cells. These findings significantly deepened my insights into MET's involvement in cellular mechanisms and disease pathology.

28/Mar/2022

rAb Production

With extensive experience in recombinant antibody production and optimization, we ensure that our services meet the highest quality standards. By delivering top-tier antibody products promptly, we support your research with reliable and efficient solutions, tailored to your specific scientific needs.

Featured Anti-MET Recombinant Antibody Production Platforms
Fig.6 Milligram-scale recombinant antibody production.

Fig.7 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs offers a wide selection of premium antibody formats to meet the varied needs of our customers. These formats encompass full-length antibodies, VH fragments, Fab, scFv, and more, providing flexible options for different research applications.

Fig.8 Full Length Anti-MET Recombinant Antibody Production and Modalities.

Drug Information Targeting MET

Table 1. Therapeutic approaches targeting MET in clinical development.

If you would like further information about our anti-MET recombinant antibody products, feel free to contact us. Our expert team is ready to assist with any questions you may have. We look forward to building a collaborative partnership that advances your research objectives.