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MET

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This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG4 - kappa
Application:
FuncS, IF, Neut, ELISA, FC, IP, WB
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
Fab / Fc - G1 - kappa
Application:
IP, IF, FuncS, FC, Neut, ELISA, ICC
Species Reactivity:
Human
Application:
Cytotoxicity assay, Function study
Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Targets:
MET & HER2
Type:
DVD-Ig
Application:
FuncS, Promising therapeutic agent
Targets:
MET & CD3
Type:
BiTE
Application:
FuncS, Promising therapeutic agent
Targets:
MET & CD3
Type:
CrossMab
Application:
FuncS, Promising therapeutic agent
Targets:
HER2 & MET
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Targets:
MET & EGFR
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & MET
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Targets:
EGFR & MET
Type:
DVD-Ig
Application:
FuncS, Promising therapeutic agent
Derivation:
Humanized
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
WB, BL, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
scFv
Application:
WB, BL, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
Fab
Application:
WB, BL, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
ADCC enhanced antibody
Application:
ELISA, Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, Neut
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, Neut
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
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