Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC
CAT#: VS-0525-YC10
This biparatopic antibody targets two separate epitopes of MET, blocking hepatocyte growth factor (HGF) binding and promoting MET internalization and degradation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET
❮
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Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human MET
- Species Reactivity
- Human
- Type
- Asymmetric hetero HC, common LC
- Valency
- 1 + 1
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- MET Proto-Oncogene, Receptor Tyrosine Kinase
Target
- Introduction
- This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers.
- Alternative Names
- DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97
- Gene ID
- 4233
- UniProt ID
- A0A024R759
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "MET"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H24 | Anti-Human MET Recombinant Antibody (TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG4 - kappa |
| TAB-190-F(E) | Anti-Human Met(Onartuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Fab / Fc - G1 - kappa |
| TAB-521CL | Anti-Human MET Recombinant Antibody (TAB-521CL) | WB, FuncS | Antibody |
| TAB-0881CLV-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0881CLV-S(P)) | ELISA, FuncS | Humanized scFv |
| TAB-0883CLV-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0883CLV-S(P)) | ELISA, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G049E | Anti-MET immunotoxin (Fab)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-271 | Human Anti-MET Recombinant Antibody (PABL-271) | WB, Block, FuncS | Human IgG |
| HPAB-1298LY | Human Anti-MET Recombinant Antibody (HPAB-1298LY) | ELISA, IP | Human IgG2 |
| HPAB-1299LY | Human Anti-MET Recombinant Antibody (HPAB-1299LY) | ELISA, IP | Human IgG2 |
| HPAB-1300LY | Human Anti-MET Recombinant Antibody (HPAB-1300LY) | ELISA, IP | Human IgG2 |
| HPAB-1301LY | Human Anti-MET Recombinant Antibody (HPAB-1301LY) | ELISA, IP | Human IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155) | ELISA, Neut | ADCC enhanced antibody |
| AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534LC | Mouse Anti-MET Recombinant Antibody (TAB-534LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-535LC | Mouse Anti-MET Recombinant Antibody (TAB-535LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-001MZ | Anti-Human MET Recombinant Antibody (DN30) | IHC, PET imaging | |
| TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
| TAB-012MZ | Mouse Anti-MET Recombinant Antibody (TAB-012MZ) | ELISA, WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002MZ | Anti-Human MET Recombinant Antibody (TAB-002MZ) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| TAB-0880CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| TAB-0880CLV-S(P) | Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P)) | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-536LC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-536LC-S(P)) | ELISA | Human scFv |
| TAB-537LC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-537LC-S(P)) | ELISA | Human scFv |
| TAB-538LC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-538LC-S(P)) | ELISA | Human scFv |
| TAB-539LC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-539LC-S(P)) | ELISA | Human scFv |
| TAB-540LC-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-540LC-S(P)) | WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC, IF, IHC-P, WB | IgG |
| MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
| MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
| MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1298LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1298LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1299LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1299LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1300LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1300LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1301LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1301LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1302LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1302LY-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP146-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-AP146-YC-F(E)) | FC, IHC | Mouse Fab |
| HPAB-AP147-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-AP147-YC-F(E)) | FC, IHC | Mouse Fab |
| HPAB-N0176-YC-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-N0176-YC-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-N0177-YC-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-N0177-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0117-WJ-F(E) | Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0117-WJ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF474 | A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY131 | Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5) | WB, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY58 | Human Anti-Met (clone 5D5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1336 | Anti-MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4357 | Anti-Mouse MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4356 | Anti-Human MET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC479 | Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) | ELISA, FC, Neut, Cell-uptake |
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