Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24)

Name: Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24)
SKU: AFC-TAB-H24
Rating: 5 (1 reviews)

CAT#: AFC-TAB-H24

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human MET

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg

Normal Tissue Figure 4 Kidney

Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

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Specifications

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Specificity
MET (met proto-oncogene, hepatocyte growth factor (HGF) receptor, HGFR, scatter factor (SF) receptor, HGF/SF receptor, receptor tyrosine-protein kinase c-met, papillary renal cell carcinoma 2, RCCP2) [Homo sapiens]

Species Reactivity
Human

Applications
FuncS, IF, Neut, ELISA, FC, IP

Conjugate
Unconjugated

Generic Name
Emibetuzumab

Related Disease
Solid tumors, advanced or metastatic

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
MET; met proto-oncogene (hepatocyte growth factor receptor); hepatocyte growth factor receptor; HGFR; RCCP2; SF receptor; HGF receptor; oncogene MET; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor

Gene ID
4233

UniProt ID
P08581

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Biosimilar Overview

Please refer to Emibetuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Emibetuzumab.

Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-H24.pdf

MSDS

MSDS - AFC-TAB-H24.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Emibetuzumab"

DrugMonitor™ Anti-Emibetuzumab Antibody (VS-1224-YC418)
Emibetuzumab has been evaluated in clinical trials for advanced cancer, including renal cell carcinoma, hepatocellular cancer, gastric adenocarcinoma, and non-small cell lung cancer. The DrugMonitor™ Anti-Emibetuzumab Antibody (VS-1224-YC418) is an anti-drug antibody (ADA) against Emibetuzumab. This drug-based antibody is raised in mice immunized with the Emibetuzumab. The anti-Emibetuzumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Emibetuzumab in samples.

See other products for "MET"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
AGTO-G049E	Anti-MET immunotoxin (Fab)-PE	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
TAB-521CL	Anti-Human MET Recombinant Antibody (TAB-521CL)	WB, FuncS	Antibody
TAB-0332CL-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P))	ELISA	Humanized scFv
TAB-026MZ-F(E)	Anti-Human MET Recombinant Antibody Fab Fragment (73R009)	WB	Humanized antibody
TAB-0881CLV-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0881CLV-F(E))	ELISA, FuncS	Humanized Fab
TAB-0883CLV-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0883CLV-F(E))	ELISA, FuncS	Humanized Fab

CAT	Product Name	Application	Type
PABZ-155	Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155)	ELISA, Neut	ADCC enhanced antibody

CAT	Product Name	Application	Type
TAB-534LC	Mouse Anti-MET Recombinant Antibody (TAB-534LC)	FC, FuncS, Inhib	Mouse IgG
TAB-535LC	Mouse Anti-MET Recombinant Antibody (TAB-535LC)	FC, FuncS, Inhib	Mouse IgG
TAB-001MZ	Anti-Human MET Recombinant Antibody (DN30)	IHC, PET imaging
TAB-011MZ	Mouse Anti-MET Recombinant Antibody (TAB-011MZ)	ELISA, WB, FC	Mouse IgG
TAB-012MZ	Mouse Anti-MET Recombinant Antibody (TAB-012MZ)	ELISA, WB, FC	Mouse IgG

CAT	Product Name	Application	Type
TAB-002MZ	Anti-Human MET Recombinant Antibody (TAB-002MZ)	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-002MZ-S(P)	Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P))	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-002MZ-F(E)	Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E))	IHC, PET imaging	Chimeric antibody (mouse/human)
TAB-0880CLV	Human Anti-MET Recombinant Antibody (TAB-0880CLV)	ELISA, FuncS	Chimeric (mouse/human) IgG1
TAB-0880CLV-S(P)	Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-0880CLV-S(P))	ELISA, FuncS	Mouse scFv

CAT	Product Name	Application	Type
TAB-536LC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-536LC-S(P))	ELISA	Human scFv
TAB-537LC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-537LC-S(P))	ELISA	Human scFv
TAB-538LC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-538LC-S(P))	ELISA	Human scFv
TAB-539LC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-539LC-S(P))	ELISA	Human scFv
TAB-540LC-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-540LC-S(P))	WB	Human scFv

CAT	Product Name	Application	Type
NEUT-1726CQ	Recombinant Rabbit Anti-MET Antibody (CBL1008)	Neut	IgG

CAT	Product Name	Application	Type
MOR-2216	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB)	ICC, IF, IHC-P, WB	IgG
MOR-4519	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS)	WB, IF, ICC	IgG
MOR-4645	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS)	WB, IF, ICC, FC, ELISA	IgG
MOR-4694	Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS)	WB, ELISA	IgG

CAT	Product Name	Application	Type
HPAB-1298LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1298LY-S(P))	ELISA, IP	Human scFv
HPAB-1299LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1299LY-S(P))	ELISA, IP	Human scFv
HPAB-1300LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1300LY-S(P))	ELISA, IP	Human scFv
HPAB-1301LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1301LY-S(P))	ELISA, IP	Human scFv
HPAB-1302LY-S(P)	Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1302LY-S(P))	ELISA, IP	Human scFv

CAT	Product Name	Application	Type
HPAB-1298LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E))	ELISA, IP	Human Fab
HPAB-1299LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E))	ELISA, IP	Human Fab
HPAB-1300LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E))	ELISA, IP	Human Fab
HPAB-1301LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E))	ELISA, IP	Human Fab
HPAB-1302LY-F(E)	Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1302LY-F(E))	ELISA, IP	Human Fab

CAT	Product Name	Application	Type
HPAB-M0153-YC	Mouse Anti-MET Recombinant Antibody (clone 3E1D7)	ELISA	Mouse IgG
HPAB-0117-WJ	Mouse Anti-MET Recombinant Antibody (HPAB-0117-WJ)	ELISA, WB	Mouse IgG, κ
HPAB-1309-FY	Human Anti-MET Recombinant Antibody (HPAB-1309-FY)	ELISA	Human IgG
HPAB-1310-FY	Human Anti-MET Recombinant Antibody (HPAB-1310-FY)	ELISA	Human IgG
HPAB-0902-WJ	Human Anti-Met Recombinant Antibody (clone 7A2)	ELISA, WB, IHC, FC	Humanized IgG2

CAT	Product Name	Application	Type
MHC-YF474	A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer	FCM

CAT	Product Name	Application	Type
VS-1024-XY131	Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5)	WB, IP	Mouse IgG1

CAT	Product Name	Application	Type
VS-0325-FY58	Human Anti-Met (clone 5D5) scFv-Fc Chimera	Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application
VS-0325-XY1336	Anti-MET Immunohistochemistry Kit	IHC
VS-0525-XY4357	Anti-Mouse MET Immunohistochemistry Kit	IHC
VS-0525-XY4356	Anti-Human MET Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC479	Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-YC10	Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA	Asymmetric hetero HC, common LC

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