Anti-MET immunotoxin (Fab)-PE
CAT#: AGTO-G049E
This immunotoxin was achieved by conjugating/fusing the Anti-MET Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to gastric cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating gastric cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- Fab-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- gastric cancer
Target
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE75
- Gene ID
- 4233
- UniProt ID
- A0A024R759
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H24 | Anti-Human MET Recombinant Antibody (TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG4 - kappa |
| TAB-190-F(E) | Anti-Human Met(Onartuzumab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | Fab / Fc - G1 - kappa |
| TAB-0332CL-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) | ELISA | Humanized scFv |
| TAB-026MZ | Anti-Human MET Recombinant Antibody (73R009) | WB | Humanized antibody |
| TAB-026MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (73R009) | WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-271 | Human Anti-MET Recombinant Antibody scFv Fragment (PSBL-271) | WB, Block, FuncS | Human scFv |
| HPAB-0123-FY-S(P) | Camelid Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0123-FY-S(P)) | ELISA | Camelid scFv |
| HPAB-1298LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1298LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1299LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1299LY-S(P)) | ELISA, IP | Human scFv |
| HPAB-1300LY-S(P) | Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-1300LY-S(P)) | ELISA, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-155 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (PABZ-155) | ELISA, Neut | ADCC enhanced antibody |
| AFC-TAB-H24 | Afuco™ Anti-MET ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H24) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-534LC | Mouse Anti-MET Recombinant Antibody (TAB-534LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-535LC | Mouse Anti-MET Recombinant Antibody (TAB-535LC) | FC, FuncS, Inhib | Mouse IgG |
| TAB-001MZ | Anti-Human MET Recombinant Antibody (DN30) | IHC, PET imaging | |
| TAB-011MZ | Mouse Anti-MET Recombinant Antibody (TAB-011MZ) | ELISA, WB, FC | Mouse IgG |
| TAB-012MZ | Mouse Anti-MET Recombinant Antibody (TAB-012MZ) | ELISA, WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-536LC | Human Anti-MET Recombinant Antibody (TAB-536LC) | Inhib | Human IgG2 |
| TAB-537LC | Human Anti-MET Recombinant Antibody (TAB-537LC) | Inhib | Human IgG2 |
| TAB-538LC | Human Anti-MET Recombinant Antibody (TAB-538LC) | Inhib | Human IgG2 |
| TAB-539LC | Human Anti-MET Recombinant Antibody (TAB-539LC) | Inhib | Human IgG2 |
| TAB-540LC | Human Anti-MET Recombinant Antibody (TAB-540LC) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-002MZ | Anti-Human MET Recombinant Antibody (TAB-002MZ) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (TAB-002MZ-S(P)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-002MZ-F(E) | Anti-Human MET Recombinant Antibody Fab Fragment (TAB-002MZ-F(E)) | IHC, PET imaging | Chimeric antibody (mouse/human) |
| TAB-0880CLV | Human Anti-MET Recombinant Antibody (TAB-0880CLV) | ELISA, FuncS | Chimeric (mouse/human) IgG1 |
| TAB-0880CLV-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) | ELISA, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1726CQ | Recombinant Rabbit Anti-MET Antibody (CBL1008) | Neut | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2216 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) | ICC, IF, IHC-P, WB | IgG |
| MOR-4519 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) | WB, IF, ICC | IgG |
| MOR-4645 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) | WB, IF, ICC, FC, ELISA | IgG |
| MOR-4694 | Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) | WB, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0760-CN | Mouse Anti-MET Recombinant Antibody (HPAB-0760-CN) | WB, ELISA, IHC, IP | Mouse IgG |
| HPAB-0761-CN | Human Anti-MET Recombinant Antibody (HPAB-0761-CN) | WB, ELISA, IHC, IP | Chimeric (mouse/human) IgG1, κ |
| HPAB-0762-CN | Human Anti-MET Recombinant Antibody (HPAB-0762-CN) | WB, ELISA, IHC, IP | Humanized IgG1, κ |
| PABC-457 | Human Anti-MET Recombinant Antibody (PABC-457) | Block, FuncS, ELISA | Human IgG1, κ |
| MRO-0989-CN | Recombinant Rabbit Anti-MET Monoclonal Antibody (CBACN-368) | WB, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030-WJ-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0030-WJ-F(E)) | ELISA, WB | Human Fab |
| HPAB-1298LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1299LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1300LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1300LY-F(E)) | ELISA, IP | Human Fab |
| HPAB-1301LY-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1301LY-F(E)) | ELISA, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY131 | Mouse Anti-NHP MET Recombinant Antibody (clone K.845.5) | WB, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY58 | Human Anti-Met (clone 5D5) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1336 | Anti-MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4357 | Anti-Mouse MET Immunohistochemistry Kit | IHC | |
| VS-0525-XY4356 | Anti-Human MET Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC479 | Recombinant Anti-MET Vesicular Antibody, EV Displayed (VS-0425-YC479) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC10 | Recombinant Anti-MET Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA | Asymmetric hetero HC, common LC |
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