This immunotoxin was achieved by conjugating/fusing the Anti-MET Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to gastric cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating gastric cancer.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H24 | Anti-Human MET Recombinant Antibody (Emibetuzumab) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG4 - kappa |
TAB-0332CL-F(E) | Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0332CL-F(E)) | ELISA | Humanized Fab |
TAB-026MZ-S(P) | Anti-Human MET Recombinant Antibody scFv Fragment (73R009) | WB | Humanized antibody |
TAB-0881CLV | Human Anti-MET Recombinant Antibody (TAB-0881CLV) | ELISA, FuncS | Humanized IgG1 |
TAB-0883CLV | Human Anti-MET Recombinant Antibody (TAB-0883CLV) | ELISA, FuncS | Humanized IgG1 |
There are currently no Customer reviews or questions for AGTO-G049E. Click the button above to contact us or submit your feedback about this product.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.