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CD123 & CD3
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.
Recombinant Anti-CD123× Anti-CD3 Bi-specific T-cell engagers (DART, MGD006) (BSAB-L009)
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- Targets: CD123 & CD3
- Type: DART
Recombinant Anti-CD123 × Anti-CD3 Bispecific Antibody (DART) (DART-L002)
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- Targets: CD123 & CD3
- Type: DART
- Application: FuncS, Promising therapeutic agent
Recombinant Anti-CD123 × Anti-CD3 Bi-specific T-cell engagers (DART, MGD006) (BSAB-L025)
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- Targets: CD123 & CD3
- Type: DART
Rat Anti-CD3 Recombinant Antibody (clone 17A2) (MOB-0202MC)
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: FC, IHC, IP, Activ, CMCD, Depletion
Mouse Anti-CD3 Recombinant Antibody (clone G8.2.38 (1).) (MOB-0271MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
Mouse Anti-CD3 Recombinant Antibody (clone SPV-T3b) (NEUT-339CQ)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, Block, IHC-Fr, IF, WB
Mouse Anti-CD3 Recombinant Antibody (clone UCHT1) (NEUT-340CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, IHC-Fr, IHC-P, ICC, IP, WB, Activ, Block
Anti-Human CD3 Therapeutic Antibody Fab Fragment (AFM15) (TAB-118CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Fab fragment
Anti-Human CD3 Therapeutic Antibody Fab Fragment (OKT3) (TAB-0416CL-F(E))
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- Application: IB, ELISA, FC, FuncS
Human Anti-Human CD3 Therapeutic Antibody Fab Fragment (TAB-0532CL-F(E))
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- Type: Human antibody
Mouse Anti-Human CD3 Therapeutic Antibody Fab Fragment (TAB-0422CL-F(E))
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- Species Reactivity: cyno CD3ε
- Application: ELISA
Mouse Anti-Human CD3 Recombinant Antibody (TAB-0422CL)
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- Species Reactivity: cyno CD3ε
- Application: ELISA
Anti-Mouse CD3 Therapeutic Antibody Fab Fragment (Dow2) (TAB-0365CL-F(E))
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- Application: IP, IB, FuncS
Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment (TAB-0417CL-S(P))
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- Type: Chimeric (mouse/human)
- Application: ELISA, FC, FuncS
Humanized Anti-Human CD3 Recombinant Antibody (TAB-0418CL)
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
Mouse Anti-Human CD3 Recombinant Antibody scFv Fragment (TAB-0422CL-S(P))
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- Species Reactivity: cyno CD3ε
- Application: ELISA
Anti-Human CD3 Therapeutic Antibody scFv Fragment (OKT3) (TAB-0416CL-S(P))
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- Application: IB, ELISA, FC, FuncS
Human Anti-Human CD3 Therapeutic Antibody scFv Fragment (TAB-0532CL-S(P))
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- Type: Human antibody
Chimeric Anti-Human CD3 Recombinant Antibody (TAB-0417CL)
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- Type: Chimeric (mouse/human)
- Application: ELISA, FC, FuncS
Anti-Human CD3 Recombinant Antibody scFv Fragment (TAB-0418CL-S(P))
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- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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