Recombinant monoclonal antibody to CD27. 2F2 is a chimeric antibody (rabbit/human) that can be potentially used in the treatment of autoimmune diseases.
Figure 1 2F2 blocks CD27 downrnodulation induced by Ramos in a dose-dependent fashion.
T cells were preactivated as in method. For CD27 downrnodulation, cells were incubated with (black bars) or without (hatched bar) irradiated Rarnos cells for 18 h. For cultures containing Rarnos cells, titrated concentrations of purified 2F2 rnAb were added as indicated on the vertical axis. Mean fluorescence plus SE of three independent experiments is shown.
HintZen, R. Q., Lens, S. M., Beckmann, M. P., Goodwin, R. G., Lynch, D., & Van Lier, R. A. (1994). Characterization of the human CD27 ligand, a novel member of the TNF gene family. The Journal of Immunology, 152(4), 1762-1773.
Figure 2 Biochemical analysis of CD27L.
Ramos cells were either irradiated (lanes B and C) or not (lanes D and E) and surface iodinated as described in Materials and Methods. Cells were lysed in 1% NP-40 buffer and immunoprecipitation was conducted using CLB-CD27/1 (lanes B and D) and 2F2 mAb (lanes C and E)-coated CNBr-activated Sepharose 48 beads. Beads coated with CLB-MH15 (lane A) were used as a control. Precipitates were analyzed under reducing conditions on a 5 to 15% SDS polyacrylamide gradient gel.
HintZen, R. Q., Lens, S. M., Beckmann, M. P., Goodwin, R. G., Lynch, D., & Van Lier, R. A. (1994). Characterization of the human CD27 ligand, a novel member of the TNF gene family. The Journal of Immunology, 152(4), 1762-1773.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2370z | Mouse Anti-CD27 Recombinant Antibody (clone 16G8) | WB, ELISA, IF, IHC | Mouse IgG1 |
HPAB-0300-CN | Human Anti-CD27 Recombinant Antibody (HPAB-0300-CN) | ELISA, FC, Block | Human IgG |
MRO-0291-CN | Rabbit Anti-CD27 Recombinant Antibody (clone JB40-98) | WB, IF, IHC, FC | Rabbit IgG |
FN-229CQ | Hamster Anti-CD27 Recombinant Antibody (clone LG.3A10) | FC, FuncS, IHC-Fr | Armenian hamster IgG |
FN-261CQ | Mouse Anti-CD27 Recombinant Antibody (clone O323) | FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H74 | Anti-Human CD27 Recombinant Antibody (Varlilumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-018LC | Human Anti-CD27 Recombinant Antibody (TAB-018LC) | ELISA | Chimeric antibody (rat/human) |
TAB-019LC | Human Anti-CD27 Recombinant Antibody (TAB-019LC) | ELISA | Chimeric antibody (rat/human) |
TAB-020LC | Human Anti-CD27 Recombinant Antibody (TAB-020LC) | ELISA | Chimeric antibody (rat/human) |
TAB-021LC | Human Anti-CD27 Recombinant Antibody (TAB-021LC) | ELISA | Chimeric antibody (rat/human) |
TAB-037LC-F(E) | Anti-Human CD27 Recombinant Antibody Fab Fragment (0152) | SPR, FC | Chimeric antibody (rabbit/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-026LC | Anti-Human CD27 Recombinant Antibody (2F2) | SPR, FC | |
TAB-027LC | Anti-Human CD27 Recombinant Antibody (5F2) | SPR, FC | |
TAB-028LC | Anti-Human CD27 Recombinant Antibody (5F32) | SPR, FC | |
TAB-029LC | Anti-Human CD27 Recombinant Antibody (11F26) | SPR, FC | |
TAB-030LC | Anti-Human CD27 Recombinant Antibody (10F13) | SPR, FC |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-022LC-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (TAB-022LC-S(P)) | ELISA | Humanized scFv |
TAB-022LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-022LC-F(E)) | ELISA | Humanized Fab |
TAB-023LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-023LC-F(E)) | ELISA | Humanized Fab |
TAB-024LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-024LC-F(E)) | ELISA | Humanized Fab |
TAB-025LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-025LC-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-320CQ | Hamster Anti-CD27 Recombinant Antibody (clone LG.7F9) | FC, FuncS, Neut | Hamster IgG |
NEUT-321CQ | Mouse Anti-CD27 Recombinant Antibody (clone MM0165-7H21) | WB, Neut, FC | Mouse IgG1 |
NEUT-322CQ | Mouse Anti-CD27 Recombinant Antibody (clone CBL803) | WB, FC, CyTOF, Neut | Mouse IgG1 |
NEUT-323CQ | Mouse Anti-CD27 Recombinant Antibody (clone CBL185) | FC, Neut, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0547 | Hi-Affi™ Rabbit Anti-CD27 Recombinant Antibody (clone DS547AB) | WB, IHC, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-096LC | Human Anti-CD27 Recombinant Antibody (MOB-096LC) | ELISA, FuncS, WB | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0299-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0299-CN-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-0300-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0300-CN-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-N0032-YC-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-N0032-YC-S(P)) | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0299-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0299-CN-F(E)) | ELISA, FC, Block | Human Fab |
HPAB-0300-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0300-CN-F(E)) | ELISA, FC, Block | Human Fab |
HPAB-N0032-YC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-N0032-YC-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H74 | Afuco™ Anti-CD27 ADCC Recombinant Antibody (Varlilumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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