Mouse Anti-CD27 Recombinant Antibody (VS-0824-YJ44)

Name: Mouse Anti-CD27 Recombinant Antibody (VS-0824-YJ44)
SKU: VS-0824-YJ44
Rating: 5 (1 reviews)

CAT#: VS-0824-YJ44

M2177 is a mouse antibody binding to CD27 ECD. MAb 2177 shows potency in neutralizing CD70-induced signaling. However, it does not block the binding of soluble CD70. The structure reveals a unique binding site of mAb 2177 at the edge of the receptor molecule, which allows the mAb to sterically block the cell-bound form of CD70 from reaching CD27 while leaving the ligand epitope clear. All reported anti-CD27 mAbs, including mAb 2177, are non-agonistic per se. CMC204 is a mouse antibody recognizing ECD of CD27. It blocks the CD27-CD70 interaction with the IC50 in the low nanomolar range.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_5_8.jpg

Normal Tissue Figure 3 High expression in lymph node.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_7_8_val_selected.jpg

Normal Tissue Figure 4 Lymph node

Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_8_8.jpg

Normal Tissue Figure 5 Tonsil

Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_5_8.jpg

RNA Expression Figure 6 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139193-CD27

RNA Expression Figure 3 RNA cell line category: Group enriched (Daudi, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139193-CD27

❮

❯

Sub Cat	Clone	Size	Conjugation	Endotoxin	Purity	Fc Engineering
VS-0824-YJ13	M2177
VS-0824-YJ14	CMC204

Specifications

Host Species
Mouse

Type
Mouse IgG1 kappa

Specificity
Human CD27

Species Reactivity
Human

Applications
Neut

Related Disease
Tumor

Product Property

Purity
>95% as determined by SDS-PAGE or SEC-HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
T14; S152; Tp55; TNFRSF7; S152. LPFS2; CD27 antigen; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7

Gene ID
939

UniProt ID
P15941

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0824-YJ44.pdf

MSDS

MSDS - VS-0824-YJ44.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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