Anti-CD184-dasatinib ADC
CAT#: ADC-077LZY
This ADC product is composed of an anti-CD184 antibody conjugated via linker to dasatinib (anti-CXCR4-dasatinib). It has demonstrated a response in immunosuppressive drug treatment by a MOA (Mechanism of Action) of selectively delivering dasatinib to human T cells with excellent in vitro immunosuppressive activity.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (Daudi, JURKAT, Karpas-707, MOLT-4, REH, U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121966-CXCR4
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Specifications
- Antibody Overview
- Humanized Anti-CXCR4 IgG with an elongated CDR3H
- Antibody Isotype
- IgG
- Antibody Conjugation
- a dasatinib disulfide-cleavable linker consists of a peptide spacer unit to increase
solubility and
an alkoxyamine group for conjugation; the antibody is modified by adding S-4FB linker
- Linker
- disulfide-cleavable linkers
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- dasatinib
- Drug Class/Description
- Class: dasatinib
Description: Dasatinib(trade name Sprycel.), also known as BMS-354825, is a cancer drug .It is an oral Bcr-Abl tyrosine kinase inhibitorand Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
Target
- Introduction
- This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Alternative Names
- CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor;
- Gene ID
- 7852
- UniProt ID
- P61073
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Datasheet
MSDS
COA
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