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IL20

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For Research Use Only. Not For Clinical Use.


Background

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
IL20
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Basal keratinocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SiHa)

Interaction

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

Molecular function

Cytokine

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