Human Anti-IL20 Recombinant Antibody (clone 15D2); Fab Fragment (CAT#: HPAB-0723-CN-F(E))
The antibody is a recombinant antibody against interleukin 20 (IL20), derived from human. It can reduce IL20 mediated activation of both IL20R1/IL20R2 and IL22R1/IL20R2 receptor complexes. It inhibits cynomolgus IL20-induced as well as mouse IL20-induced proliferation of the BaF-3(hIL20R) cells, while hIL19 or hIL24-induced proliferation of BaF-3(hIL20R) was not inhibited by 15D2.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/ihc_selected.jpg
(Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/ihc_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_B_7_5.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_9_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_4.jpg
(Cholangiocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (SiHa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162891-IL20
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162891-IL20
Specifications
- Immunogen
- Human IL-20
- Host Species
- Human
- Type
- Human Fab
- Specificity
- Human IL20
- Species Reactivity
- Human, Cynomolgus, Mouse
- Clone
- 15D2
- Applications
- WB, ELISA, Neut
- Related Disease
- Autoimmune, Inflammatory diseases
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0009CL | Human Anti-IL20 Recombinant Antibody (TAB-0009CL) | Inhib, IB, FC, RIA | Humanized Antibody |
| TAB-0009CL-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (TAB-0009CL-F(E)) | Inhib, ELISA, SPR | Humanized Fab |
| TAB-565LC | Anti-human IL20 Recombinant Antibody (TAB-565LC) | ELISA, Inhib, FuncS | Humanized antibody |
| TAB-565LC-S(P) | Anti-human IL20 scFv Fragment (TAB-565LC-S(P)) | ELISA | Humanized antibody |
| TAB-565LC-F(E) | Anti-human IL20 Fab Fragment (TAB-565LC-F(E)) | ELISA | Humanized antibody |
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