Mouse Anti-NRG1 Recombinant Antibody (VS-0224-FY18) (CAT#: VS-0224-FY18)
This monoclonal antibody is a mouse IgG2a that specifically targets a 44 kD protein identified as NRG1 (Neuregulin 1)/ Heregulin/Neu Differentiation Factor/NDF. Mab has been designed to interact with over 30 protein families, but it has exhibited staining exclusively in glial cells.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows weak positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
(Immunohistochemical staining of human caudate shows weak positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
Figure 4 Cerebellum
(Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
(Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
Specifications
- Immunogen
- The immunogen is recombinant extracellular domain of rat NDF protein.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human, Mouse and Rat NRG1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Immunohistochemistry, Immunoprecipitation
- Conjugate
- Unconjugated
- Related Disease
- Cancer, schizophrenia, and bipolar disorde
Product Property
- Purity
- >95%
- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.08% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western blot: 1-5 μg/ml
Immunoprecipitation: 2 μl/mg of lysate
Immunohistochemistry: 1/10-1/500
Target
- Alternative Names
- Neuregulin 1; Pro-NRG1; HRGA; SMDF; HGL; GGF; NDF; NRG1 Intronic Transcript 2 (Non-Protein Coding); Heregulin, Alpha (45kD, ERBB2 P185-Activator); Acetylcholine Receptor-Inducing Activity; Pro-Neuregulin-1, Membrane-Bound Isoform
- Gene ID
- 3084
- UniProt ID
- Q02297
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Mouse Antibody Products
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-579MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-579MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-580MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-580MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-581MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-581MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-582MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-582MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-579MZ-F(E) | Mouse Anti-NRG1 Recombinant Antibody; Fab Fragment (TAB-579MZ-F(E)) | ELISA, FC | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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