Mouse Anti-NRG1 Recombinant Antibody (VS-0224-FY18)
CAT#: VS-0224-FY18
This monoclonal antibody is a mouse IgG2a that specifically targets a 44 kD protein identified as NRG1 (Neuregulin 1)/ Heregulin/Neu Differentiation Factor/NDF. Mab has been designed to interact with over 30 protein families, but it has exhibited staining exclusively in glial cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/1446_D11_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human caudate
Immunohistochemical staining of human caudate shows weak positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_7_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_7_5.jpg
Normal Tissue
Figure 4 Cerebellum
Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Purkinje cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_B_8_8.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10964/27907_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A549, BJ, fHDF/TERT166, GAMG, U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000157168-NRG1
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Specifications
- Immunogen
- The immunogen is recombinant extracellular domain of rat NDF protein.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human, Mouse and Rat NRG1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Immunohistochemistry, Immunoprecipitation
- Conjugate
- Unconjugated
- Related Disease
- Cancer, schizophrenia, and bipolar disorde
Product Property
- Purity
- >95%
- Format
- Liquid
- Concentration
- 0.2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.08% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western blot: 1-5 μg/ml
Immunoprecipitation: 2 μl/mg of lysate
Immunohistochemistry: 1/10-1/500
Target
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Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "NRG1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-579MZ | Mouse Anti-NRG1 Recombinant Antibody (TAB-579MZ) | ELISA, FC, WB | Mouse IgG |
| TAB-579MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-579MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-580MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-580MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-581MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-581MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-582MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-582MZ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-583MZ | Human Anti-NRG1 Recombinant Antibody (TAB-583MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-584MZ | Human Anti-NRG1 Recombinant Antibody (TAB-584MZ) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| TAB-583MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-583MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-584MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-584MZ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-585MZ-S(P) | Mouse Anti-NRG1 Recombinant Antibody; scFv Fragment (TAB-585MZ-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-586MZ | Anti-Human NRG1 Recombinant Antibody (538.24) | ELISA, Inhib, SPR | Human antibody |
| TAB-587MZ | Anti-Human NRG1 Recombinant Antibody (538.24.71) | ELISA, Inhib, SPR, FuncS | Human antibody |
| TAB-586MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (538.24) | ELISA | Human antibody |
| TAB-587MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (538.24.71) | ELISA | Human antibody |
| TAB-588MZ-S(P) | Anti-Human NRG1 Recombinant Antibody scFv Fragment (526.9) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4349 | Hi-Affi™ Recombinant Rabbit Anti-NRG1 Monoclonal Antibody (SI439DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0522-LC114 | Mouse Anti-NRG1 Recombinant Antibody (VS-0522-LC114) | ICC, WB | Mouse IgG2a |
| VS-0522-LC115 | Rat Anti-NRG1 Recombinant Antibody (VS-0522-LC115) | ICC, WB | Rat IgG2b |
| VS-0522-LC116 | Human Anti-NRG1 Recombinant Antibody (VS-0522-LC116) | ICC, WB | Human IgG1 |
| VS-0522-LC117 | Rabbit Anti-NRG1 Recombinant Antibody (VS-0522-LC117) | ICC, WB | Rabbit IgG |
| VS-0723-WK111 | Rabbit Anti-NRG1 Recombinant Antibody (VS-0723-WK111) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY26 | Human Anti-NRG1 (clone 526.9) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC115 | Recombinant Anti-NRG1 Vesicular Antibody, EV Displayed (VS-0425-YC115) | ELISA, FC, SPR, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4980 | Anti-NRG1 Immunohistochemistry Kit | IHC |
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