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POU5F1
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- Rabbit Anti-POU5F1 Polyclonal Antibody (MRO-2092-CN) (MRO-2092-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, CHIP
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- Recombinant Mouse Anti-POU5F1 Antibody (clone 2D9H4) (VS3-FY1172)
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- Type: Mouse IgG1
- Application: ELISA, ICC, FC
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- Recombinant Mouse Anti-POU5F1 Antibody (clone 3C1F5) (VS3-FY1173)
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- Type: Mouse IgG1
- Application: ELISA, IHC, FC
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- Recombinant Mouse Anti-POU5F1 Antibody (VS-0923-FY125) (VS-0923-FY125)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-POU5F1 Recombinant Antibody (clone 41B1) (VS11-QX120)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: IHC, WB
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- Mouse Anti-POU5F1 Recombinant Antibody (clone 3A5) (VS3-XY1280)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-POU5F1 Recombinant Antibody (clone 5F7) (VS3-XY1281)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-POU5F1 Recombinant Antibody (clone 7E7) (VS3-XY1282)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, ICC
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- Mouse Anti-POU5F1 Monoclonal Antibody (clone 5F7) (VS7-0425-WR518)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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- Mouse Anti-POU5F1 Monoclonal Antibody (clone 7E7) (VS7-0425-WR519)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, FC
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- Mouse Anti-POU5F1 Monoclonal Antibody (clone 3A5) (VS7-0425-WR520)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-POU5F1 Monoclonal Antibody (clone 1D10H6) (VS7-0425-WR521)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Mouse Anti-POU5F1 Monoclonal Antibody (VS7-0425-WR651) (VS7-0425-WR651)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, ICC, FC, ELISA
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- Mouse Anti-POU5F1 Recombinant Antibody (VS7-0425-WR652) (VS7-0425-WR652)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, FC, IF, ICC
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- Anti-POU5F1 Immunohistochemistry Kit (VS-0525-XY5587)
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- Species Reactivity: Human
- Target: POU5F1
- Application: IHC
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- Anti-Mouse POU5F1 Immunohistochemistry Kit (VS-0525-XY5588)
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- Species Reactivity: Human, Mouse, Rabbit, Monkey
- Target: POU5F1
- Application: IHC
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- Rabbit Anti-POU5F1 Recombinant Antibody (clone AFY0036) (MOR-0065-FY)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SuSa)
Interaction
Interacts with PKM. Interacts with WWP2. Interacts with UBE2I and ZSCAN10 (By similarity). Interacts with PCGF1 (PubMed:26687479). Interacts with ESRRB; recruits ESRRB near the POU5F1-SOX2 element in the NANOG proximal promoter; the interaction is DNA independent (By similarity). Interacts with ZNF322 (By similarity). Interacts with MAPK8 and MAPK9; the interaction allows MAPK8 and MAPK9 to phosphorylate POU5F1 on Ser-355 (By similarity). Interacts (when phosphorylated on Ser-355) with FBXW8 (By similarity). Interacts with FBXW4 (By similarity). Interacts with SOX2 and SOX15; binds synergistically with either SOX2 or SOX15 to DNA (By similarity).
Molecular function
Developmental protein, DNA-binding
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