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    SMAD5

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
    Protein class

    Transcription factors

    Predicted location

    Intracellular

    Single cell type specificity

    Low cell type specificity

    Immune cell specificity

    Immune cell enhanced (basophil)

    Cell line specificity

    Low cell line specificity

    Interaction

    May form trimers with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit and SMURF1. Interacts with SUV39H1 and SUV39H2. Interacts (via MH2 domain) with LEMD3. Interacts with WWP1. Interacts with TMEM119 (By similarity). Interacts with ZNF8 (PubMed:12370310). Interacts with RANBP3L (PubMed:25755279).

    Molecular function

    DNA-binding

    More Types Infomation
    Related Signaling Pathways
    TGF-β Signaling Pathway TGF-β Signaling Pathway
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