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IL20

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
IL20
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Basal keratinocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SiHa)

Interaction

Forms a 1:1:1 heterotrimeric complex with its primary high-affinity heterodimeric receptor IL20RA/IL20RB.

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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