Ankyrin repeat scaffold protein anti-Human IL13
CAT#: SAR-L262
The Ankyrin repeat that bound IL13 was isolated from the library using ribosome display techonology. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. After affinity maturation, Ankyrin repeat variants were identified having affinities (KD=1.7 pM) for IL13 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
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Specifications
- Scaffold Name
- Ankyrin repeat
- Origin
- Ankyrin repeat proteins
- Core Structure
- 2α-helices, β-turn
- Variable Regions
- b-turn,1a-helix and loop
- Target
- IL13
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 1.7 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
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Related Diseases
Asthma
Inflammatory Bowel Diseases
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H05 | Anti-Human IL13 Recombinant Antibody (Anrukinzumab) | ELISA, Inhib | IgG1 |
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| TAB-044ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-044ZJ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-045ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-045ZJ-F(E)) | ELISA, Block | Humanized Fab |
| TAB-046ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-046ZJ-F(E)) | ELISA, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| PSBL-598 | Mouse Anti-IL13 Recombinant Antibody (clone C836); scFv Fragment | Neut | Mouse scFv |
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| PSBL-601 | Mouse Anti-IL13 Recombinant Antibody (clone X836); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0033-WJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0033-WJ-S(P)) | ELISA, WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-232 | Human Anti-IL13 Recombinant Antibody (clone M1295); Fab Fragment | WB, IHC, FuncS | Human Fab |
| HPAB-0227CQ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (HPAB-0227CQ-F(E)) | ELISA, Neut, FC, FuncS | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022ZJ | Anti-Human IL-13 Recombinant Antibody (C836) | ELISA | |
| TAB-022ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836) | ELISA | |
| TAB-023ZJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (TAB-023ZJ-S(P)) | ELISA, Block | Mouse scFv |
| TAB-022ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836) | ELISA | |
| TAB-023ZJ-F(E) | Mouse Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-023ZJ-F(E)) | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-094ZJ | Anti-Human IL-13 Recombinant Antibody (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-067ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (CNTO 607) | ELISA, Inhib | Human antibody |
| TAB-068ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (01471/G6) | ELISA, Neut | Human antibody |
| TAB-069ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-069ZJ-F(E)) | ELISA, Neut, FC | Human Fab |
| TAB-070ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-070ZJ-F(E)) | ELISA, Neut, FC | Human Fab |
| TAB-017ML | Anti-Human IL13 Recombinant Antibody (TAB-017ML) | ELISA, IHC, FC, IP, IF, Inhib | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1171CQ | Mouse Anti-IL13 Recombinant Antibody (clone B-B13) | ELISA, ELISPOT, Neut | Mouse IgG1 |
| NEUT-1172CQ | Mouse Anti-IL13 Recombinant Antibody (clone 10X28) | Neut, WB | Mouse IgG1 |
| NEUT-1173CQ | Mouse Anti-IL13 Recombinant Antibody (NEUT-1173CQ) | Neut | Mouse IgG2b |
| NEUT-1174CQ | Mouse Anti-IL13 Recombinant Antibody (clone 32116.11) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1175CQ | Rat Anti-IL13 Recombinant Antibody (clone 5A2) | Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1790 | Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB) | WB, ICC, FC, IP | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| AFC-TAB-219 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-219) | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
| AFC-TAB-218 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-218) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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