Ankyrin repeat scaffold protein anti-Human IL13
CAT#: SAR-L262
The Ankyrin repeat that bound IL13 was isolated from the library using ribosome display techonology. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin repeats mediate protein–protein interactions and are among the most common structural motifs in known proteins. After affinity maturation, Ankyrin repeat variants were identified having affinities (KD=1.7 pM) for IL13 as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/475_E8_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42421/477_E8_1_blue_red_green.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000169194-IL13
❮
❯
Specifications
- Scaffold Name
- Ankyrin repeat
- Origin
- Ankyrin repeat proteins
- Core Structure
- 2α-helices, β-turn
- Variable Regions
- b-turn,1a-helix and loop
- Target
- IL13
- Species Reactivity
- Human
- Expression Host
- BL21 (DE3) cells
- Affinity Constant
- 1.7 pM
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for SAR-L262. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Asthma
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL13"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-218 | Anti-Human IL13 Recombinant Antibody (Tralokinumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - lambda |
| TAB-068ZJ | Anti-Human IL-13 Recombinant Antibody (01471/G6) | WB, ELISA, Neut | Human antibody |
| TAB-069ZJ | Human Anti-IL13 Recombinant Antibody (TAB-069ZJ) | ELISA, Neut, FC | Human IgG |
| TAB-070ZJ | Human Anti-IL13 Recombinant Antibody (TAB-070ZJ) | ELISA, Neut, FC | Human IgG |
| PABX-115-S (P) | Recombinant Human Anti-IL-13 Antibody scFv Fragment (C836) | WB, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H05 | Anti-Human IL13 Recombinant Antibody (Anrukinzumab) | ELISA, Inhib | IgG1 |
| TAB-219 | Anti-Human IL13 Recombinant Antibody (TAB-219) | ELISA, Neut, IF, IP, FC, FuncS | IgG4 - kappa |
| TAB-043ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (Lc6Hc2) | ELISA | Humanized antibody |
| TAB-044ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-044ZJ-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-045ZJ-F(E) | Human Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-045ZJ-F(E)) | ELISA, Block | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-170 | Human Anti-IL13 Recombinant Antibody (clone CNTO607); Fab Fragment | ELISA, WB, Neut | Human Fab |
| HPAB-0033-WJ-F(E) | Mouse Anti-IL13 Recombinant Antibody; Fab Fragment (HPAB-0033-WJ-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-1739-FY-S(P) | Mouse Anti-IL13 Recombinant Antibody (clone mAb13.2); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-1740-FY-S(P) | Human Anti-IL13 Recombinant Antibody (clone ch13.2); Fab Fragment | Inhib, ELISA | Chimeric (mouse/human) Fab |
| HPAB-1741-FY-S(P) | Human Anti-IL13 Recombinant Antibody (clone h13.2v1); Fab Fragment | Inhib, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-598 | Mouse Anti-IL13 Recombinant Antibody (clone C836); scFv Fragment | Neut | Mouse scFv |
| PSBL-600 | Human Anti-IL13 Recombinant Antibody (clone H2L6); scFv Fragment | ELISA | Humanized scFv |
| PSBL-601 | Mouse Anti-IL13 Recombinant Antibody (clone X836); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| HPAB-0286-YJ-S(P) | Human Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0286-YJ-S(P)) | ELISA, Antagonist, FuncS | Human scFv |
| HPAB-0287-YJ-S(P) | Mouse Anti-IL13 Recombinant Antibody; scFv Fragment (HPAB-0287-YJ-S(P)) | ELISA, Neut, Inhib, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022ZJ | Anti-Human IL-13 Recombinant Antibody (C836) | ELISA | |
| TAB-023ZJ | Mouse Anti-IL13 Recombinant Antibody (TAB-023ZJ) | ELISA, Block | Mouse IgG |
| TAB-022ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (C836) | ELISA | |
| TAB-022ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (C836) | ELISA | |
| TAB-023ZJ-F(E) | Mouse Anti-IL13 Recombinant Antibody; Fab Fragment (TAB-023ZJ-F(E)) | ELISA, Block | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-094ZJ | Anti-Human IL-13 Recombinant Antibody (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-S(P) | Anti-Human IL-13 Recombinant Antibody scFv Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| TAB-094ZJ-F(E) | Anti-Human IL-13 Recombinant Antibody Fab Fragment (167) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1171CQ | Mouse Anti-IL13 Recombinant Antibody (clone B-B13) | ELISA, ELISPOT, Neut | Mouse IgG1 |
| NEUT-1172CQ | Mouse Anti-IL13 Recombinant Antibody (clone 10X28) | Neut, WB | Mouse IgG1 |
| NEUT-1173CQ | Mouse Anti-IL13 Recombinant Antibody (NEUT-1173CQ) | Neut | Mouse IgG2b |
| NEUT-1174CQ | Mouse Anti-IL13 Recombinant Antibody (clone 32116.11) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1175CQ | Rat Anti-IL13 Recombinant Antibody (clone 5A2) | Neut | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1790 | Rabbit Anti-IL13 Recombinant Antibody (clone DS1790AB) | WB, ICC, FC, IP | Rabbit IgG |
| MOR-4610 | Rabbit Anti-IL13 Recombinant Antibody (clone TH123DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0226CQ | Human Anti-IL13 Recombinant Antibody (HPAB-0226CQ) | ELISA, Neut, FC, FuncS | Human IgG2 |
| HPAB-0227CQ | Human Anti-IL13 Recombinant Antibody (HPAB-0227CQ) | ELISA, Neut, FC, FuncS | Human IgG2 |
| HPAB-0228CQ | Mouse Anti-IL13 Recombinant Antibody (clone MJ2-7) | ELISA, FC, Neut, FuncS | Mouse IgG |
| HPAB-0229CQ | Human Anti-IL13 Recombinant Antibody (clone huMJ2-7) | ELISA, FC, DB, Neut, FuncS | Humanized IgG1, κ |
| HPAB-0230CQ | Mouse Anti-IL13 Recombinant Antibody (clone C65) | ELISA, FC, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H05 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H05) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-017ML | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-017ML) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| AFC-TAB-219 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-219) | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
| AFC-TAB-218 | Afuco™ Anti-IL13 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-218) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY129 | CytoStream™ Rat Anti-IL13 Recombinant Antibody (clone JES10-5A2) | ELISA, FC, Neut, IHC, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY124 | Human Anti-IL13 (clone IMA-638) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3484 | Anti-IL13 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC216 | Recombinant Anti-IL13 Biparatopic Antibody, Tandem scFv (Anrukinzumab x Clone IMA-026) | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC165 | Recombinant Anti-IL13 Eliminating Antibody, pH-Sensitive (VS-0625-YC165) | Antigen-Sweeping In Vivo. | Human IgG4 lambda |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IF, IHC, WB
Application: FC, IA, IF, IP, IHC, FuncS
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: WB, IHC-Fr, IHC-P, ICC, IF
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
