Recombinant Anti-human BSG Intrabody [Tat]
CAT#: IAB-B050(T)
Recombinant anti-BSG intrabody in fusion with HIV Tat works within cells to bind a human leukocyte surface molecule BSG, expressed in CHO cells. The intrabody has the ability to down-regulate EMMPRIN cell surface expression on colorectal cancer cell.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Normal Tissue
Figure 2 Testis
Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Normal Tissue
Figure 3 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
❮
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Specifications
- Immunogen
- human basigin (Ok blood group)
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Products can be used for: Western blot; Immunocytochemistry; Functional studies
Product Property
- Purity
- >95%, by SDS-PAGE with Coomassie Brilliant Blue staining
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- BSG; basigin (Ok blood group); M6; OK; 5F7; TCSF; CD147; EMMPRIN; basigin; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6; extracellular matrix metalloproteinase inducer; tumor cell-derived collagena
- Gene ID
- 682
- UniProt ID
- P35613
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B050(A) | Recombinant Anti-human BSG Intrabody [(D-Arg)9] | WB, ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B050(G) | Recombinant Anti-human BSG Intrabody [+36 GFP] | IF, FC, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156 | Anti-Human CD147 Recombinant Antibody (TAB-156) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-461 | Human Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | WB, FuncS | Chimeric (mouse/human) Fab |
| PFBC-403 | Mouse Anti-BSG Recombinant Antibody (clone 6H8); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-3079LY-F(E) | Mouse Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-3079LY-F(E)) | IHC, Inhib | Mouse Fab |
| HPAB-3080LY-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-3080LY-F(E)) | IHC, Inhib | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1285CL-F(E) | Anti-Human BSG Recombinant Antibody Fab Fragment (2.6.1 (ABX-RB2)) | Inhib | Fully human antibody |
| TAB-1287CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1287CL-F(E)) | FC | Human Fab |
| TAB-1288CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1288CL-F(E)) | FC | Human Fab |
| TAB-1289CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1289CL-F(E)) | FC | Human Fab |
| TAB-1290CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1290CL-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-070CQ | Human Anti-BSG Recombinant Antibody (clone Ab-1) | ELISA, Block | Human IgG1, κ |
| NEUT-071CQ | Mouse Anti-BSG Recombinant Antibody (clone HIM6) | FC, WB, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0389 | Hi-Affi™ Rabbit Anti-BSG Recombinant Antibody (clone DS389AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-020CN | Mouse Anti-BSG Recombinant Antibody (clone 5F6) | ELISA, Block, FuncS | Mouse IgG1 |
| NS-020CN-F(E) | Mouse Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0438-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0438-YC-S(P)) | ELISA, IHC, Inhib | Human scFv |
| HPAB-M0439-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0439-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0440-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0440-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0441-YC-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-M0441-YC-S(P)) | ELISA | Human scFv |
| HPAB-3079LY-S(P) | Mouse Anti-BSG Recombinant Antibody; scFv Fragment (HPAB-3079LY-S(P)) | IHC, Inhib | Mouse scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-156 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-156) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-883 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-883) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3188LY | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01) | ELISA, FC | Humanized IgG |
| HPAB-3189LY | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-02) | ELISA, FC | Humanized IgG |
| VS3-FY241 | Recombinant Mouse Anti-BSG Antibody (clone 2D3A9) | ELISA, WB, IHC, ICC, FC | Mouse IgG1 |
| VS3-FY242 | Recombinant Mouse Anti-BSG Antibody (clone 2D8C11) | ELISA, IHC, FC | Mouse IgG2b |
| VS3-FY243 | Recombinant Mouse Anti-BSG Antibody (clone 5A6F8) | ELISA, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1484 | AbPlus™ Anti-BSG Magnetic Beads (VS-0724-YC1484) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY33 | Human Anti-BSG (clone HAb18) scFv-Fc Chimera | ELISA, IF, WB | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC238 | Recombinant Anti-BSG Vesicular Antibody, EV Displayed (VS-0425-YC238) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY837 | Anti-Mouse BSG Immunohistochemistry Kit | IHC | |
| VS-0525-XY838 | Anti-Rat BSG Immunohistochemistry Kit | IHC |
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