Anti-Human BSG Recombinant Antibody (2.6.1 (ABX-RB2))
CAT#: TAB-1285CL
This antibody specifically binding to CD147 results in the killing of T-cells, B-cells, and/or monocytes. So it can also be used in the treatment of graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.
Published Data
Gene Expression
Figure 1 A graph comparing the activity of the ABX-CBL antibody and the 2.6.1 antibody (also referred to as cem 2.6) in inhibiting the MLR assay. The data demonstrate that the 2.6.1 antibody is not an effective inhibitor.
Inhib
Figure 2 A comparison of the activity of the ABX-CBL antibody and the 2.6.1 multimeric IgM antibody (also known as ABX-Rb2) in inhibiting the MLR assay, demonstrating that the 2.6.1 multimeric IgM antibody is effective in inhibition of MLR.
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Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Normal Tissue
Figure 2 Testis
Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Normal Tissue
Figure 3 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
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Specifications
- Immunogen
- CEM cells
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Clone
- 2.6.1 (ABX-RB2)
- Applications
- Inhib
- Related Disease
- Graft versus host disease (GVHD), organ transplant rejection diseases (such as renal transplant, ocular transplant), cancers (such as cancers of the blood (i.e., leukemias and lymphomas), pancreatic), autoimmune diseases, inflammatory diseases
Applications
- Application Notes
- This antibody has been tested for use in Inhibition.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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|---|---|---|---|
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|---|---|---|---|
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