Human Anti-BSG (clone HAb18) scFv-Fc Chimera
CAT#: VS-0125-FY33
The anti-CD147 scFv-Fc product can be widely applied in biomedical research, including fundamental research, targeted therapy, and diagnostic tools. In fundamental research, it can help explore the functions of CD147 in cell biology. Additionally, due to its high specificity, these antibodies have the potential to be developed as targeted therapeutic tools for CD147-related diseases, such as certain cancers. Furthermore, as biomarkers, they show promising applications in cell detection, particularly in studies of the tumor microenvironment, helping to assess the expression levels of CD147. These observations indicate that antibodies obtained through biological screening have effective recognition capabilities for membrane proteins, laying a solid foundation for subsequent experiments and applications.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Normal Tissue
Figure 2 Testis
Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Normal Tissue
Figure 3 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- HAb18
- Applications
- ELISA, Immunofluorescence, Western Blot
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- In the study of MDA-MB-453 cells, experimental results indicated that these antibodies could specifically bind to cells expressing CD147, with no significant binding to CD147-negative cells. Further gene editing experiments showed that when CD147 was eliminated, the binding ability of these antibodies was significantly reduced, confirming their specificity. Preliminary research also indicated that these antibodies possess potential internalization capabilities, which may allow for internalization during the targeting of cancer cells. These characteristics provide new insights for future cancer treatment and the development of targeted drugs. These findings further underscore the potential value and application prospects of CD147 as a cancer target.
Target
- Alternative Names
- Basigin (Ok Blood Group); Tumor Cell-Derived Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; Leukocyte Activation Antigen M6; Collagenase Stimulatory Factor; OK Blood Group Antigen; Basigin; EMMPRIN
- Gene ID
- 682
- UniProt ID
- P35613
- Cellular Localization
- Cell membrane; Cell projection; Endoplasmic reticulum; Endosome; Membrane
- Post Translation Modifications
- Isoform 2: N-glycosylated.
Isoform 3: N-glycosylated.
Isoform 4: N-glycosylated.
- Protein Refseq
- NP_001309172.1; NP_001719.2; NP_940991.1
- Function
- Isoform 1:
Essential for normal retinal maturation and development (By similarity).
Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors.
In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.
May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes.
Isoform 2
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells.
Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane.
Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling.
Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells.
Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone HAb18"
- CAT
- Product Name
See other products for "BSG"
Select a product category from the dropdown menu below to view related products.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| HPAB-3188LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01); scfv Fragment | ELISA, FC | Humanized scfv |
| HPAB-3189LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-02); scfv Fragment | ELISA, FC | Humanized scfv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0126CQ-F(E) | Mouse Anti-BSG Recombinant Antibody (clone HAb18); Fab Fragment | ELISA, IF | Mouse Fab |
| PFBC-403 | Mouse Anti-BSG Recombinant Antibody (clone 6H8); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-M0438-YC-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (HPAB-M0438-YC-F(E)) | ELISA, IHC, Inhib | Humanized Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| MRO-1735-CN | Rabbit Anti-BSG Polyclonal Antibody (MRO-1735-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-066CQ | Mouse Anti-BSG Recombinant Antibody (clone UM-8D6) | FC, FuncS, IP, WB | Mouse IgG1 |
| HPAB-3188LY | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01) | ELISA, FC | Humanized IgG |
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| TAB-1288CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1288CL-F(E)) | FC | Human Fab |
| TAB-1289CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1289CL-F(E)) | FC | Human Fab |
| TAB-1290CL-F(E) | Human Anti-BSG Recombinant Antibody; Fab Fragment (TAB-1290CL-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| AFC-TAB-883 | Afuco™ Anti-BSG ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-883) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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| CAT | Product Name | Application | Type |
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