Mouse Anti-BSG Recombinant Antibody (clone 5F6) (CAT#: NS-020CN)
Recombinant monoclonal antibody to CD133. This product is an IgG1 antibody that is useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
Specific Inquiry
Figure 1 Bar graphs of murine antibody (10 ug/ml) binding (mlgGl) to live MDA-MB-231 cells.
Block
Figure 2 The relative ability of selected purified murine antibodies (mlgGl) block CD147 (CD147) stimulated MMP-I production in NHLF.
FuncS
Figure 3 Zymogram showing MMP-2 release in co-cultures of human tumor and human fibroblast cells in attenuated by recombinant anti-CD147 antibodies 2H3(mIgG2a) and 5F6(hIgGl).
FuncS
Figure 4 Anti-CD147 antibodies 2H3(mIgG2a) and 5F6(hIgGl) inhibit CD 147 induced VEGF from NHLF.
FuncS
Figure 5 The hemoglobin (Hb) content on Day 8 in Matrigel plugs implanted with PANC-I (human pancreatic tumor cells) taken from nude mice after receiving lOmg/kg Mabs injected Lp., on Days 1 and 4.
FuncS
Figure 6 Tumor volume change over time in mice receiving recombinant anti-CD 147 antibodies, 2H3(mIgG2a) and 5F6(hIgGl), which are effector positive isotypes (E+) or PBS.
ELISA
Figure 7 Competitive binding assays of 2H3 Mab in competition with 4A5 or 5F6 for binding of the Aspl9-Glu 192-Fc construct in an ELISA format.
Specifications
- Immunogen
- Recombinant human CD147
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human
- Species Reactivity
- Human
- Clone
- 5F6
- Applications
- ELISA, Block, FuncS
- Related Disease
- Malignant disease
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Enzyme-linked Immunosorbent Assay, Blocking, Functional Assay.
Target
- Alternative Names
- Basigin (Ok Blood Group); Tumor Cell-Derived Collagenase Stimulatory Factor; Extracellular Matrix Metalloproteinase Inducer; Leukocyte Activation Antigen M6; Collagenase Stimulatory Factor; OK Blood Group Antigen; CD147 Antigen; EMMPRIN; TCSF; 5F7; Ok Blood Group; Basigin; CD147; M6; OK
- Gene ID
- 862
- UniProt ID
- P35613
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B050(A) | Recombinant Anti-human BSG Intrabody [(D-Arg)9] | WB, ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B050(G) | Recombinant Anti-human BSG Intrabody [+36 GFP] | IF, FC, FuncS | scFv-(+36GFP) |
| IAB-B050(T) | Recombinant Anti-human BSG Intrabody [Tat] | WB, ICC, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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