Anti-CD79b (SN8)-vc-MMAE ADC (RG7596)
CAT#: ADC-L029
This ADC product is composed of an anti-CD79b antibody (clone SN8) conjuagated via a vc linker to MMAE (SN8-vc-MMAE). It has demonstrated a response in hematological malignancies. DLBCL and follicular NHL treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra and weak to moderate in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in cells of the germinal center corona.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9751/ihc_selected.jpg
Normal Tissue
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/48_C6_1_blue_red_green.jpg
Normal Tissue
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/47_C6_1_blue_red_green.jpg
Normal Tissue
Figure 6 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_3.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007312-CD79B
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Specifications
- Antibody Overview
- Humanized IgG1k antibody trastuzumab (Anti-HER2)
- Clone
- SN8
- Antibody Conjugation
- Humanized
- Linker
- vc (valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linkers-Peptide linkers
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described.
- Alternative Names
- B29; IGB; AGM6
- Gene ID
- 974
- UniProt ID
- P40259
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Related Signaling Pathways
BCR Signaling Pathway
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MSDS
COA
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- CAT
- Product Name
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|---|---|---|---|
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| FAMAB-0058YC | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16) | FuncS | Hamster IgG |
| FN-062CQ | Mouse Anti-CD79B Recombinant Antibody (clone SN8) | FC, FuncS, WB | Mouse IgG1, κ |
| HPAB-1059-FY | Mouse Anti-CD79B Recombinant Antibody (HPAB-1059-FY) | FC | Mouse IgG |
| VS-0723-WK2 | Human Anti-CD79b Recombinant Antibody (clone Polatuzumab) | FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-897 | Humanized Anti-CD79B Recombinant Antibody (TAB-897) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Humanized (from mouse) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0581 | Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
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| MHC-LC1918 | PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058-YC-S(P) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); scFv Fragment | FuncS | Hamster scFv |
| HPAB-1059-FY-F(E) | Mouse Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-1059-FY-F(E)) | FC | Mouse Fab |
| HPAB-J0055-YC-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-J0055-YC-S(P)) | ELISA, FC, Inhib, FuncS | Humanized scFv |
| HPAB-J0056-YC-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-J0056-YC-S(P)) | ELISA, FC, Inhib, FuncS | Humanized scFv |
| HPAB-J0057-YC-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-J0057-YC-S(P)) | ELISA, FC, Inhib, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0058-YC-F(E) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); Fab Fragment | FuncS | Hamster Fab |
| HPAB-0364LY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-0364LY-F(E)) | Inhib, ELISA | Human Fab |
| HPAB-618-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-618-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-619-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-619-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-N0044-YC-F(E) | Human Anti-CD79b Recombinant Antibody; Fab Fragment (HPAB-N0044-YC-F(E)) | FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-897 | Afuco™ Anti-CD79B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-897) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY72 | CytoStream™ Mouse Anti-CD79B Recombinant Antibody (clone CB3-1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY74 | Human Anti-CD79B (clone P2C2) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY1222 | Anti-Mouse CD79B Immunohistochemistry Kit | IHC |
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