Anti-CD79b (clone SN8)-SPP-DM1 ADC
CAT#: ADC-201LZY
This ADC product is composed of an anti-CD79b antibody (clone SN8) conjugated via SPP linker to DM1 (SN8-SPP-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra and weak to moderate in reaction center cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in cells of the germinal center corona.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9751/ihc_selected.jpg
Normal Tissue
Figure 4 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/48_C6_1_blue_red_green.jpg
Normal Tissue
Figure 5 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to Nucleoplasm &
Plasma membrane & Cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/47_C6_1_blue_red_green.jpg
Normal Tissue
Figure 6 Colon
Mucosal lymphoid cells
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_3.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/44107/169682_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000007312-CD79B
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Specifications
- Antibody Overview
- Mouse Anti-CD79b IgG1,SN8
- Clone
- SN8
- Antibody Isotype
- IgG1
- Linker
- SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 974
- UniProt ID
- P40259
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Related Signaling Pathways
BCR Signaling Pathway
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MSDS
COA
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| CAT | Product Name | Application | Type |
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| FAMAB-0058-YC-F(E) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); Fab Fragment | FuncS | Hamster Fab |
| HPAB-0364LY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-0364LY-F(E)) | Inhib, ELISA | Human Fab |
| HPAB-618-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-618-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-619-FY-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-619-FY-F(E)) | FC, ELISA | Humanized Fab |
| HPAB-1491-FY-S(P) | Human Anti-CD79B Recombinant Antibody scFv Fragment (HPAB-1491-FY-S(P)) | ELISA, WB | Human scFv |
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| HPAB-618-FY | Human Anti-CD79B Recombinant Antibody (HPAB-618-FY) | FC, ELISA | Human IgG |
| HPAB-619-FY | Human Anti-CD79B Recombinant Antibody (HPAB-619-FY) | FC, ELISA | Humanized IgG |
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| VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
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