Anti-CD79b (clone SN8)-mc-MMAF ADC

CAT#: ADC-204LZY

This ADC product is composed of an anti-CD79b antibody (clone SN8) conjugated via mc linker to MMAF (SN8-mc-MMAF). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.

Gene Expression
Figure 1 IF staining of human cell line REH Figure 2 IHC staining of human lymph node Figure 3 IHC staining of human lymph node Figure 4 IF staining of human cell line A-431 Figure 5 IF staining of human cell line U-2 OS Figure 6 Colon Figure 7 Lymph node Figure 8 RNA cell line category: Cell line enhanced (Daudi, REH, U-698)

Specifications

  • Antibody Overview
  • Mouse Anti-CD79b IgG1(SN8)
  • Clone
  • SN8
  • Antibody Isotype
  • IgG1
  • Linker
  • mc(maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • MMAF (monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS
Inquiry
Navs

Customer Review

Submit a review or a question

There are currently no Customer reviews or questions for ADC-204LZY. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Article title:
DOI/PubMed URL:
Email:
Name:

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Related Signaling Pathways

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone SN8"

See other products for "CD79B"

Select a product category from the dropdown menu below to view related products.

CAT Product Name Application Type
TAB-897 Humanized Anti-CD79B Recombinant Antibody (TAB-897) Neut, ELISA, IF, IP, FuncS, FC, ICC Humanized (from mouse) IgG1, κ
CAT Product Name Application Type
MOR-0581 Hi-Affi™ Rabbit Anti-CD79B Recombinant Antibody (clone DS581AB) WB, IHC, ICC, IP, FC Rabbit IgG
CAT Product Name Application Type
MHC-LC1918 PE-A*02:01/Human CD79B (LLSAEPVPA) MHC Tetramer FCM
CAT Product Name Application Type
AFC-TAB-897 Afuco™ Anti-CD79B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-897) Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody
CAT Product Name Application Type
VS-0225-XY72 CytoStream™ Mouse Anti-CD79B Recombinant Antibody (clone CB3-1) FC Mouse IgG1, kappa
CAT Product Name Application Type
VS-0325-FY74 Human Anti-CD79B (clone P2C2) scFv-Fc Chimera IA Human IgG1, scFv-Fc
CAT Product Name Application Type
VS-0425-YC74 Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) ELISA, FC, Neut, Cell-uptake
CAT Product Name Application Type
VS-0525-XY1222 Anti-Mouse CD79B Immunohistochemistry Kit IHC
Specific Inquiry
Go to compare Add to compare

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Go to compare

Go to compare