Anti-CD79b (clone SN8)-mc-MMAF ADC
CAT#: ADC-204LZY
This ADC product is composed of an anti-CD79b antibody (clone SN8) conjugated via mc linker to MMAF (SN8-mc-MMAF). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9178/1889_C4_3_selected.jpg
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Specifications
- Antibody Overview
- Mouse Anti-CD79b IgG1(SN8)
- Clone
- SN8
- Antibody Isotype
- IgG1
- Linker
- mc(maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- MMAF (monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);
- Gene ID
- 974
- UniProt ID
- P40259
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Related Signaling Pathways
BCR Signaling Pathway
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Datasheet
MSDS
COA
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| HPAB-619-FY-S(P) | Human Anti-CD79B Recombinant Antibody; scFv Fragment (HPAB-619-FY-S(P)) | FC, ELISA | Humanized scFv |
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| HPAB-1059-FY-F(E) | Mouse Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-1059-FY-F(E)) | FC | Mouse Fab |
| CAT | Product Name | Application | Type |
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| FAMAB-0058-YC-F(E) | Hamster Anti-Cd79b Recombinant Antibody (clone HM79-16); Fab Fragment | FuncS | Hamster Fab |
| HPAB-1491-FY-S(P) | Human Anti-CD79B Recombinant Antibody scFv Fragment (HPAB-1491-FY-S(P)) | ELISA, WB | Human scFv |
| HPAB-J0055-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0055-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
| HPAB-J0056-YC-F(E) | Human Anti-CD79B Recombinant Antibody; Fab Fragment (HPAB-J0056-YC-F(E)) | ELISA, FC, Inhib, FuncS | Humanized Fab |
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| CAT | Product Name | Application | Type |
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| AFC-TAB-897 | Afuco™ Anti-CD79B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-897) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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| VS-0225-XY72 | CytoStream™ Mouse Anti-CD79B Recombinant Antibody (clone CB3-1) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
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| VS-0325-FY74 | Human Anti-CD79B (clone P2C2) scFv-Fc Chimera | IA | Human IgG1, scFv-Fc |
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| VS-0425-YC74 | Recombinant Anti-CD79B Vesicular Antibody, EV Displayed (VS-0425-YC74) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY1222 | Anti-Mouse CD79B Immunohistochemistry Kit | IHC |
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