Anti-CD79b (clone SN8)-MCC-DM1 ADC (CAT#: ADC-202LZY)

• Antibody Overview
• Mouse Anti-CD79b IgG1,SN8

• Clone
• SN8

• Antibody Isotype
• IgG1

• Linker
• MCC(Maleimidomethyl cyclohexane-1-carboxylate)

• Linker Class/Description
• Class: Noncleavable linker
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation

• Drug
• DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta);

• Gene ID
• 974

• UniProt ID
• P40259

• ADC-089LCT
• Anti-CD79 (bSN8)-mcc-DM1 ADC

• ADC-201LZY
• Anti-CD79b (clone SN8)-SPP-DM1 ADC

• ADC-203LZY
• Anti-CD79b (clone SN8)-mc-vc-PABC-MMAE ADC

• ADC-204LZY
• Anti-CD79b (clone SN8)-mc-MMAF ADC

• ADC-L029
• Anti-CD79b (SN8)-vc-MMAE ADC (RG7596)

• FN-062CQ
• Mouse Anti-CD79B Recombinant Antibody (clone SN8)

Select a product category from the dropdown menu below to view related products.