Anti-Human CXCR2 Therapeutic Single Domain Antibody (CAT#: TAB-202CL)
Recombinant Humanized monoclonal Single Domain Antibody expressed in E. coli binding to Human CXCR2. The anti-CXC chemokine receptor 2 (CXCR2; IL8RB) antibodiess in combination with other cancer immunotherapies can prevent migration of myeloid-derived suppressor cells and increased the efficacy of programmed cell death 1-targeting mAbs in a mouse model of rhabdomyosarcoma.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane, microtubules & mitotic spindle.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31999/1855_E6_15_cr5ad88637398d2_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to plasma membrane, microtubules & mitotic spindle.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31999/1855_E6_15_cr5ad88637398d2_selected.jpg
Figure 2 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/1855_F6_25_cr5ad88701bb05e_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/1855_F6_25_cr5ad88701bb05e_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_5.jpg
Figure 4 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_A_8_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_A_8_8.jpg
Figure 5 High expression in spleen
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_4.jpg
(Cells in red pulp Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32017/139603_B_9_4.jpg
Figure 6 RNA cell line category: Group enriched (BEWO, HL-60, HMC-1, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000180871-CXCR2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000180871-CXCR2
Specifications
- Derivation
- Humanized
- Type
- Single Domain Antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8
- Gene ID
- 3579
- UniProt ID
- P25025
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CXCR2"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-050 | Recombinant Anti-Human CXCR2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-002MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (2B2) | FC, Inhib | Single domain antibody |
| TAB-004MZ-VHH | Anti-Human CXCR2 Recombinant Antibody (54B12) | ELISA, IHC, FuncS, SPR | Single domain antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-117MZ | Anti-Human CXCR2 Recombinant Antibody (HY29) | FC, FuncS, Inhib | Humanized antibody |
| TAB-118MZ | Anti-Human CXCR2 Recombinant Antibody (HY29GL) | FC, FuncS, Inhib | Humanized antibody |
| TAB-117MZ-S(P) | Anti-Human CXCR2 Recombinant Antibody scFv Fragment (HY29) | ELISA | Humanized antibody |
| TAB-118MZ-S(P) | Anti-Human CXCR2 Recombinant Antibody scFv Fragment (HY29GL) | ELISA | Humanized antibody |
| TAB-117MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (HY29) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-119MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (CX2-Mab#1) | ELISA | Human antibody |
| TAB-120MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (CX2-Mab#2) | ELISA | Human antibody |
| TAB-121MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (CX2-Mab#3) | ELISA | Human antibody |
| TAB-122MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (CX2-Mab#4) | ELISA | Human antibody |
| TAB-123MZ-F(E) | Anti-Human CXCR2 Recombinant Antibody Fab Fragment (CX2-Mab#5) | ELISA | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2067MZ | Recombinant Mouse Anti-Human CXCR2 Antibody (clone 20) | ELISA, ELISA, FC, IHC-P, WB | Mouse antibody |
| HPAB-0306-YC | Human Anti-CXCR2 Recombinant Antibody (clone HY29) | ELISA, FC, FuncS | Humanized IgG1 |
| HPAB-0417-CN | Human Anti-CXCR2 Recombinant Antibody (clone ZY05KA-G08) | ELISA | Chimeric (mouse/human) IgG |
| VS-0723-WK66 | Human Anti-CXCR2 Recombinant Antibody (VS-0723-WK66) | FC | Chimeric (rabbit/human) IgG1 |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-671CQ | Mouse Anti-CXCR2 Recombinant Antibody (clone CBL044) | FC, IHC, Neut | Mouse IgG2 |
| NEUT-672CQ | Mouse Anti-CXCR2 Recombinant Antibody (clone MM0222-7J40) | IHC-Fr, Neut, FC | Mouse IgG2a |
| NEUT-673CQ | Mouse Anti-CXCR2 Recombinant Antibody (clone CBL790) | FC, IHC, CyTOF®, Neut | Mouse IgG2a |
| NEUT-674CQ | Mouse Anti-CXCR2 Recombinant Antibody (clone CBL791) | Neut, FC | Mouse IgG2a |
| NEUT-675CQ | Rat Anti-Cxcr2 Recombinant Antibody (clone CBL867) | FC, Neut | Rat IgG2 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0306-YC-S(P) | Human Anti-CXCR2 Recombinant Antibody (clone HY29); scFv Fragment | ELISA, FC, FuncS | Humanized scFv |
| HPAB-0417-CN-S(P) | Mouse Anti-CXCR2 Recombinant Antibody (clone ZY05KA-G08); scFv Fragment | ELISA | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0306-YC-F(E) | Human Anti-CXCR2 Recombinant Antibody (clone HY29); Fab Fragment | ELISA, FC, FuncS | Humanized Fab |
| HPAB-0417-CN-F(E) | Human Anti-CXCR2 Recombinant Antibody (clone ZY05KA-G08); Fab Fragment | ELISA | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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