Human Anti-CXCR5 Recombinant Antibody (clone 40C01-VH2-Vk3) (CAT#: HPAB-0115-LSX)
Recombinant monoclonal antibody to CXCR5. Clone 40C01-VH2-Vk3 is a human monoclonal antibody that can be potentially used in treatment or prevention of CXCR5 related diseases or disorders.
Specific Inquiry
Inhib
Figure 1 Inhibition of CXCL13-stimulated chemotaxis of L1.2 cells expressing-human (panel A to F) and cynomolgus monkey (G and H) CXCR5, caused by anti-CXCR5 40C01-VH1-Vk3 and 40C01-VH2-Vk3 variants expressed in a whole antibody format as IgG1, IgG2 and IgG4.
The results were normalized for basal activity (medium alone) and the maximal response obtained with 10 nM CXCL13 (100%). The displayed data are representative of three independent experiments. All points were run in triplicate (error bars indicate ±S.E.M).
Inhib
Figure 2 Inhibition of human CXCL13-stimulated chemotaxis of primary human B cells caused by anti-CXCR5 40C01-VH1-Vk3 (panel A) and 40C01-VH2-Vk3 (panel B) variants expressed in a whole antibody format as IgG1.
The results are expressed as calculated IC50s (half maximal inhibitory concentration). Values are the means±S.E.M from 8 (40C01-VH1-Vk3) and 5 (40C01-VH2-Vk3) separate experiments respectively.
Figure 3 Binding of Alexa-Fluor 647 labelled anti-CXCR5 40C01 variants to HEK-293 cells stably transfected with human CXCR5.
Figure 4 Binding of Alexa-Fluor 647-labelled anti-CXCR5 40C01 variants to human B cells in whole blood.
Figure 5 Binding of anti-CXCR5 40C01 variants to cynomolgus monkey B cells in whole blood.
Inhib
Figure 6 Inhibition of CXCL13-stimulated ERK phosphorylation in B cells in human whole blood by anti-CXCR5 mAbs.
Inhib
Figure 7 Inhibition of CXCL13-stimulated ERK phosphorylation in B cells in cynomolgus monkey whole blood by anti-CXCR5 mAbs.
Specifications
- Immunogen
- Human and Macaque CXCR5
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human CXCR5
- Species Reactivity
- Human, Monkey
- Clone
- 40C01-VH2-Vk3
- Applications
- FC, Inhib
- Related Disease
- Autoimmune, inflammatory diseases, cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Inhibition.
Target
- Alternative Names
- Chemokine (C-X-C Motif) Receptor 5; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5); Burkitt Lymphoma Receptor 1, GTP-Binding Protein; Monocyte-Derived Receptor 15; CXC-R5; CXCR-5; MDR-15; MDR15; BLR1; Burkitt Lymphoma Receptor 1; CD185 Antigen; CD185
- Gene ID
- 643
- UniProt ID
- P32302
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1702z | Mouse Anti-CXCR5 Recombinant Antibody (clone 28C11) | FC, ICC, IHC, Neut | Mouse IgG2b |
| MOB-2070MZ | Recombinant Mouse Anti-Human CXCR5 Antibody (clone 62606.222) | FC | Mouse antibody |
| HPAB-0109-LSX | Mouse Anti-CXCR5 Recombinant Antibody (clone 2C9) | ELISA, WB, Inhib | Mouse IgG |
| VS3-FY431 | Recombinant Rabbit Anti-CXCR5 Antibody (clone R03-8K7) | WB | Rabbit IgG |
| VS-0723-WK68 | Human Anti-CXCR5 Recombinant Antibody (VS-0723-WK68) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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