Human Anti-CXCR5 Recombinant Antibody (clone 40C01-VH2-Vk3) (CAT#: HPAB-0115-LSX)
Recombinant monoclonal antibody to CXCR5. Clone 40C01-VH2-Vk3 is a human monoclonal antibody that can be potentially used in treatment or prevention of CXCR5 related diseases or disorders.
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Inhib
Figure 1 Inhibition of CXCL13-stimulated chemotaxis of L1.2 cells expressing-human (panel A to F) and cynomolgus monkey (G and H) CXCR5, caused by anti-CXCR5 40C01-VH1-Vk3 and 40C01-VH2-Vk3 variants expressed in a whole antibody format as IgG1, IgG2 and IgG4.
The results were normalized for basal activity (medium alone) and the maximal response obtained with 10 nM CXCL13 (100%). The displayed data are representative of three independent experiments. All points were run in triplicate (error bars indicate ±S.E.M).
Inhib
Figure 2 Inhibition of human CXCL13-stimulated chemotaxis of primary human B cells caused by anti-CXCR5 40C01-VH1-Vk3 (panel A) and 40C01-VH2-Vk3 (panel B) variants expressed in a whole antibody format as IgG1.
The results are expressed as calculated IC50s (half maximal inhibitory concentration). Values are the means±S.E.M from 8 (40C01-VH1-Vk3) and 5 (40C01-VH2-Vk3) separate experiments respectively.
Figure 3 Binding of Alexa-Fluor 647 labelled anti-CXCR5 40C01 variants to HEK-293 cells stably transfected with human CXCR5.
Figure 4 Binding of Alexa-Fluor 647-labelled anti-CXCR5 40C01 variants to human B cells in whole blood.
Figure 5 Binding of anti-CXCR5 40C01 variants to cynomolgus monkey B cells in whole blood.
Inhib
Figure 6 Inhibition of CXCL13-stimulated ERK phosphorylation in B cells in human whole blood by anti-CXCR5 mAbs.
Inhib
Figure 7 Inhibition of CXCL13-stimulated ERK phosphorylation in B cells in cynomolgus monkey whole blood by anti-CXCR5 mAbs.
Specifications
- Immunogen
- Human and Macaque CXCR5
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human CXCR5
- Species Reactivity
- Human, Monkey
- Clone
- 40C01-VH2-Vk3
- Applications
- FC, Inhib
- Related Disease
- Autoimmune, inflammatory diseases, cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Inhibition.
Target
- Alternative Names
- Chemokine (C-X-C Motif) Receptor 5; Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C Motif) Receptor 5); Burkitt Lymphoma Receptor 1, GTP-Binding Protein; Monocyte-Derived Receptor 15; CXC-R5; CXCR-5; MDR-15; MDR15; BLR1; Burkitt Lymphoma Receptor 1; CD185 Antigen; CD185
- Gene ID
- 643
- UniProt ID
- P32302
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1702z | Mouse Anti-CXCR5 Recombinant Antibody (clone 28C11) | FC, ICC, IHC, Neut | Mouse IgG2b |
| MOB-2070MZ | Recombinant Mouse Anti-Human CXCR5 Antibody (clone 62606.222) | FC | Mouse antibody |
| MRO-0406-CN | Rabbit Anti-CXCR5 Recombinant Antibody (clone JB11-40) | WB, IHC, FC | Rabbit IgG |
| VS3-FY431 | Recombinant Rabbit Anti-CXCR5 Antibody (clone R03-8K7) | WB | Rabbit IgG |
| VS-0723-WK68 | Human Anti-CXCR5 Recombinant Antibody (VS-0723-WK68) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
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