Anti-GD2 Antibody-Cytokine Fusion Protein, IgG-IL2
CAT#: ACFP-SH002
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-GD2 IgG to IL2. The chimeric protein is composed of two protein chains: the chimeric mouse-dog light chain; and the chimeric mouse-dog heavy chain fused to dog IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the GD2 as well as the biological activity of IL2. It improved Fc-Receptor binding and improved ADCC effector function, are useful in the treatment of GD2-expressing cancers in dogs. This immunocytokine was designed for treating GD2-expressing cancers.
Specifications
- Target
- GD2
- Molecule Class
- L kappa; IgG1-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 14.18
- Related Disease
- GD2-expressing cancers
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Dog
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Disialoganglioside GD2; Ganglioside G2; GD2
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Datasheet
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COA
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Lot Number:
See other products for "Clone 14.18"
- CAT
- Product Name
See other products for "GD2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-770-sdAb | Recombinant Anti-Human GD2 VHH Single Domain Antibody | Neut, ChiP, IP, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-731 | Anti-GD2 Recombinant Antibody (TAB-731) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L018R | anti-GD2 immunotoxin 14G2a (IgG)-RTA | Cytotoxicity assay, Functional assay |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-304CL | Anti-Human GD2 Recombinant Antibody (hu14.18K322A) | FC, FuncS | Antibody |
| PABX-059 | Human Anti-GD2 Recombinant Antibody (PABX-059) | FuncS | IgG1, κ |
| PABX-059-F (E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (PABX-059-F (E)) | FC, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a) | ELISA, WB, FuncS | Mouse IgG |
| PABL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8) | FC, ELISA, FuncS | Mouse IgG |
| HPAB-0701-CN | Human Anti-GD2 Recombinant Antibody (clone AB527) | ELISA, FC, IHC, IF | Human IgM |
| HPAB-0027-WJ | Mouse Anti-GD2 Recombinant Antibody (HPAB-0027-WJ) | ELISA, RIA | Mouse IgG3, κ |
| HPAB-1524WJ | Human Anti-GD2 Recombinant Antibody (clone KM8138) | ELISA, WB | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| PSBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); scFv Fragment | WB, FuncS | Mouse scFv |
| MOB-181CQ | Human Anti-GD2 Recombinant Antibody (MOB-181CQ) | ELISA, FC, FuncS | Humanized scFv |
| HPAB-0027-WJ-S(P) | Mouse Anti-GD2 Recombinant Antibody; scFv Fragment (HPAB-0027-WJ-S(P)) | ELISA, RIA | Mouse scFv |
| HPAB-1030WJ-S(P) | Mouse Anti-GD2 Recombinant Antibody; scFv Fragment (HPAB-1030WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-100 | Mouse Anti-GD2 Recombinant Antibody (clone 14G2a); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
| PFBL-101 | Mouse Anti-GD2 Recombinant Antibody (clone 3F8); Fab Fragment | FC, ELISA, FuncS | Mouse Fab |
| PFBZ-049 | Mouse Anti-GD2 Recombinant Antibody (clone ME36.1); Fab Fragment | WB, FuncS | Mouse Fab |
| FAMAB-0126-YC-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 7A4); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1030WJ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (HPAB-1030WJ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-075CQ | Human Anti-GD2 Recombinant Antibody (TAB-075CQ) | ELISA, FC | Human IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-074CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-074CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-075CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-075CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-076CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-076CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-077CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-077CQ-F(E)) | ELISA, FC | Human Fab |
| TAB-078CQ-F(E) | Human Anti-GD2 Recombinant Antibody; Fab Fragment (TAB-078CQ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-029CN | Mouse Anti-GD2 Recombinant Antibody (clone 5F11) | WB | Mouse IgG |
| NS-030CN | Mouse Anti-GD2 Recombinant Antibody (clone 3G6) | WB | Mouse IgG |
| NS-029CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); Fab Fragment | WB | Mouse Fab |
| NS-030CN-F(E) | Mouse Anti-GD2 Recombinant Antibody (clone 3G6); Fab Fragment | WB | Mouse Fab |
| NS-029CN-S(P) | Mouse Anti-GD2 Recombinant Antibody (clone 5F11); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-731 | Afuco™ Anti-GD2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-731) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY63 | Human Anti-GD2 (clone 3F8) scFv-Fc Chimera | FC, ELISA, FuncS, ADCC, Cyt | Human IgG1, scFv-Fc |
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