Recombinant Human Anti-HIV-1 Antibody scFv Fragment (2G12) (CAT#: PABX-087-S (P))
Anti-HIV-1 antibody is a Human of scFv class that binds to an HIV-1. This antibody neutralizes a broad range of HIV-1 isolates.
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Figure 1 Processing of anti-HIV-2 mAbs by N. benthamiana PLCPs.
mAb 2F5 or 2G12 (200 ng) was incubated with NbALP (50 ng), NbCathB (51 ng) or with no enzyme added (control) for the indicated times and then analysed by immunoblotting with antibodies to the heavy chain of human IgG. The migration positions of selected mȔ
Niemer, M., Mehofer, U., Verdianz, M., Porodko, A., Schähs, P., Kracher, D., ... & Mach, L. (2016). Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease. Biochimie, 122, 119-125.
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Figure 2 Staining of 2G12 mAb and 9205 mAb on MT-4 cells 4 days after infection with HIV-1 strain NL4.4, HE, MN, and NDK.
MFI of the background fluorescence (blue histograms), for the 2G12 mAb binding (red histograms) and for the 9206 mAb binding (green histograms) are indicated.
Huskens, D., Van Laethem, K., Vermeire, K., Balzarini, J., & Schols, D. (2007). Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12. Virology, 360(2), 294-304.
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Figure 3 Ribbon diagrams showing the N-glycosylation site mutations (red balls) in gp120 of 2G12 mAb-exposed HIV-1 strains (left panel, 3 mutations) and the mannose-binding plant lectin-exposed HIV-1 strains (right panel, 15 mutations).
The left panel shows the 24 putative glycosylation sites represented by yellow circles and their accompanying amino acid number. The red circles indicate the deleted N-glycosylation sites that appear under 2G12 mAb in the 4 different HIV-2 isolates.
The r
Huskens, D., Van Laethem, K., Vermeire, K., Balzarini, J., & Schols, D. (2007). Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12. Virology, 360(2), 294-304.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- scFv
- Specificity
- Tested positive against native DENV
- Species Reactivity
- Human immunodeficiency virus 1
- Clone
- 2G12
- Applications
- WB 1:1000-1:5000
ELISA 1:3000-1:15000
FuncS (assay dependent)
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- Assay-depended
Target
- Alternative Names
- HIV-1; human immunodeficiency virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (PNBL-038) | WB, FuncS | Llama VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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