Interleukin-18 (IL-18) was originally described in 1989 as interferon-gamma inducing factor (IGIF) and is a pro-inflammatory cytokine with various functions in addition to an ability to induce interferon gamma. These biological properties include activation of NF-κb, Fas ligand expression, the induction of both CC and CXC chemokines, and increased production of competent human immunodeficiency virus.
Figure 1 shows the potency of three different anti-IL-18 antibodies in neutralizing the biologic effects of IL-18 as a function of inhibition of IFN-γ induction in KG1 cells.
The IC50 values for the antibodies 125H (boxes) and the 2E1 antibody as an IgG antibody (circles) or as a single chain antibody (triangles) are, respectively, 2.1E-10, 9.0E-10, and 3.3E-9.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-081 | Mouse Anti-IL18 Recombinant Antibody (clone 125-2H); Fab Fragment | ELISA, Neut | Mouse Fab |
PFBL-602 | Human Anti-IL18 Recombinant Antibody (clone YC127); Fab Fragment | WB, ELISA, FuncS | Human Fab |
HPAB-0065-YC-F(E) | Human Anti-IL18 Recombinant Antibody (clone LT28); Fab Fragment | ELISA, RIA, IHC, FuncS, Neut | Human Fab |
HPAB-1273LY-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-1273LY-F(E)) | ELISA, Inhib | Human Fab |
HPAB-1274LY-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (HPAB-1274LY-F(E)) | ELISA, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0373CL | Human Anti-IL18 Recombinant Antibody (TAB-0373CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0374CL | Human Anti-IL18 Recombinant Antibody (TAB-0374CL) | ELISA, FuncS, Inhib | Human IgG |
TAB-0373CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0373CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
TAB-0374CL-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (TAB-0374CL-S(P)) | ELISA, FuncS, Inhib | Human scFv |
TAB-0373CL-F(E) | Human Anti-IL18 Recombinant Antibody; Fab Fragment (TAB-0373CL-F(E)) | ELISA, FuncS, Inhib | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0290MZ | Chicken Anti-Interleukin-18 Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1238CQ | Rabbit Anti-IL18 Recombinant Antibody (clone 1072F) | Neut | Rabbit IgG |
NEUT-1239CQ | Rat Anti-Il18 Recombinant Antibody (clone 39-3F) | Neut, WB | Rat IgG2a |
NEUT-1240CQ | Mouse Anti-IL18 Recombinant Antibody (clone CBL670) | Neut | Mouse IgG2a |
NEUT-1241CQ | Rat Anti-Il18 Recombinant Antibody (clone YIGIF74-1G7) | Neut | Rat IgG2a |
NEUT-1242CQ | Rat Anti-Il18 Recombinant Antibody (clone 93-10C) | IP, Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4248 | Rabbit Anti-IL18 Recombinant Antibody (clone SI327DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0229-CN | Human Anti-IL18 Recombinant Antibody (clone 1I1G) | WB, ELISA | Human IgG, λ |
FAMAB-0230-CN | Human Anti-IL18 Recombinant Antibody (clone 3I1E) | WB, ELISA | Human IgG, κ |
FAMAB-0231-CN | Human Anti-IL18 Recombinant Antibody (clone 4I3E) | WB, ELISA | Human IgG, κ |
FAMAB-0232-CN | Human Anti-IL18 Recombinant Antibody (clone 5I4E) | WB, ELISA | Human IgG, κ |
FAMAB-0041JF | Human Anti-IL18 Recombinant Antibody (clone h18-108) | WB, IF, IHC, ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0062-YJ-S(P) | Mouse Anti-IL18 Recombinant Antibody (clone 13G9); scFv Fragment | IA, Neut | Mouse scFv |
HPAB-0064-YJ-S(P) | Rat Anti-IL18 Recombinant Antibody (clone 14B7); scFv Fragment | IA, Neut | Rat scFv |
HPAB-0070-YJ-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (HPAB-0070-YJ-S(P)) | ELISA, Neut, IP, FC | Human scFv |
HPAB-0855-FY-F(E) | Human Anti-IL18 Recombinant Antibody (clone 2.5); scFv Fragment | ELISA | Human scFv |
HPAB-1546WJ-S(P) | Human Anti-IL18 Recombinant Antibody; scFv Fragment (clone #125-2HmAb) | ELISA, WB | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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