Recombinant Anti-IL18 (AA 37-50 x AA 64-80) Biparatopic Antibody, Tandem scFv (Clone LT28 x Clone 2E1) (CAT#: VS-0525-YC111)

• Host Animal 1
• Human

• Host Animal 2
• Human

• Specificity
• Human IL18

• Species Reactivity
• Human

• Type
• Tandem scFv

• Valency
• 1 + 1

• Clone 1
• LT28

• Clone 2
• 2E1

• Epitope 1
• aa 37-50, YFGKLESKLSVIRN

• Epitope 2
• aa 64-80, PLFEDMTDSDCR

• Purity
• >90%

• Purification
• Affinity purified

• Applications
• ELISA, IHC, Neut

• Concentration
• Lot specific

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.

• Long Name
• Interleukin 18

• Introduction
• Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

• Alternative Names
• IGIF; IL-18; IL-1g; IL1F4

• Gene ID
• 3606

• UniProt ID
• Q14116

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