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Humanized Anti-MET Recombinant Antibody (clone Onartuzumab (OA5D5.v2)); Fab Fragment (CAT#: PSBZ-155)

Recombinant Humanized Antibody (Onartuzumab (OA5D5.v2)) scFv Fragment is specific to MET. Onartuzumab, derived from the 5D5 antibody previously shown to bind the MET Sema domain (15), has shown preclinical activity in glioblastoma (GBM), pancreatic cancer, and non–small-cell lung cancer (NSCLC), among other tumor types.


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  • Gene Expression
  • Datasheet
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/55607/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/if_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18577/if_selected.jpg
Normal Tissue
Figure 4 Kidney
Figure 4 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5282/15802_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
Figure 6 RNA cell line category: Cell line enhanced (A-431, CAPAN-2)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105976-MET

Specifications

  • Immunogen
  • Human MET proto-oncogene, receptor tyrosine kinase
  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Human scFv
  • Specificity
  • Tested positive against MET
  • Species Reactivity
  • Human
  • Clone
  • Onartuzumab (OA5D5.v2)
  • Applications
  • ELISA, Neut

Product Property

  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term.

Target

  • Alternative Names
  • MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase;

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-H24 Anti-Human MET Recombinant Antibody (Emibetuzumab) FuncS, IF, Neut, ELISA, FC, IP, WB IgG4 - kappa
TAB-0332CL Human Anti-MET Recombinant Antibody (TAB-0332CL) ELISA Humanized Antibody
TAB-0332CL-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (TAB-0332CL-S(P)) ELISA Humanized scFv
TAB-0881CLV Human Anti-MET Recombinant Antibody (TAB-0881CLV) ELISA, FuncS Humanized IgG1
TAB-0883CLV Human Anti-MET Recombinant Antibody (TAB-0883CLV) ELISA, FuncS Humanized IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-G049E Anti-MET immunotoxin (Fab)-PE Cytotoxicity assay, Function study

ADCC Enhanced Antibody

CAT Product Name Application Type
PABZ-155 Afuco™ Anti-MET ADCC Recombinant Antibody (Onartuzumab), ADCC Enhanced ELISA, Neut ADCC enhanced antibody
AFC-TAB-H24 Afuco™ Anti-MET ADCC Recombinant Antibody (Emibetuzumab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC, IP ADCC enhanced antibody

Human Antibody

CAT Product Name Application Type
TAB-0530CL-F(E) Anti-Human MET Recombinant Antibody Fab Fragment ELISA, FC, IF, FuncS
TAB-536LC-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-536LC-F(E)) ELISA Human Fab
TAB-537LC-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-537LC-F(E)) ELISA Human Fab
TAB-538LC-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-538LC-F(E)) ELISA Human Fab
TAB-539LC-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-539LC-F(E)) ELISA Human Fab

Chimeric Antibody

CAT Product Name Application Type
TAB-002MZ Anti-Human MET Recombinant Antibody (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-S(P) Anti-Human MET Recombinant Antibody scFv Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-002MZ-F(E) Anti-Human MET Recombinant Antibody Fab Fragment (MvDN30) IHC, PET imaging Chimeric antibody (mouse/human)
TAB-0880CLV Human Anti-MET Recombinant Antibody (TAB-0880CLV) ELISA, FuncS Chimeric (mouse/human) IgG1
TAB-0880CLV-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (TAB-0880CLV-F(E)) ELISA, FuncS Chimeric (mouse/human) Fab

Mouse Antibody

CAT Product Name Application Type
TAB-011MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-011MZ-S(P)) ELISA, WB, FC Mouse scFv
TAB-012MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-012MZ-S(P)) ELISA, WB, FC Mouse scFv
TAB-027MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-027MZ-S(P)) FC, WB, ELISA Mouse scFv
TAB-028MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-028MZ-S(P)) FC, WB, ELISA Mouse scFv
TAB-029MZ-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (TAB-029MZ-S(P)) FC, WB, ELISA Mouse scFv

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1726CQ Recombinant Rabbit Anti-MET Antibody (CBL1008) Neut IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2216 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (DS2216AB) ICC/IF, IHC-P, WB IgG
MOR-4519 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH27DS) WB, IF, ICC IgG
MOR-4645 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH158DS) WB, IF, ICC, FC, ELISA IgG
MOR-4694 Hi-Affi™ Recombinant Rabbit Anti-MET Monoclonal Antibody (TH208DS) WB, ELISA IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0760-CN-F(E) Mouse Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0760-CN-F(E)) WB, ELISA, IHC, IP Mouse Fab
HPAB-0761-CN-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0761-CN-F(E)) WB, ELISA, IHC, IP Human Fab
HPAB-0762-CN-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-0762-CN-F(E)) WB, ELISA, IHC, IP Human Fab
HPAB-1298LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1298LY-F(E)) ELISA, IP Human Fab
HPAB-1299LY-F(E) Human Anti-MET Recombinant Antibody; Fab Fragment (HPAB-1299LY-F(E)) ELISA, IP Human Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-1298LY Human Anti-MET Recombinant Antibody (HPAB-1298LY) ELISA, IP Human IgG2
HPAB-1299LY Human Anti-MET Recombinant Antibody (HPAB-1299LY) ELISA, IP Human IgG2
HPAB-1300LY Human Anti-MET Recombinant Antibody (HPAB-1300LY) ELISA, IP Human IgG2
HPAB-1301LY Human Anti-MET Recombinant Antibody (HPAB-1301LY) ELISA, IP Human IgG2
HPAB-1302LY Human Anti-MET Recombinant Antibody (HPAB-1302LY) ELISA, IP Human IgG2

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-N0176-YC-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-N0176-YC-S(P)) ELISA, FC Mouse scFv
HPAB-N0177-YC-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-N0177-YC-S(P)) ELISA, FC Humanized scFv
HPAB-0394-YJ-S(P) Human Anti-MET Recombinant Antibody (clone S1); scFv Fragment ELISA, WB, IP, FC Human scFv
HPAB-0486-FY-S(P) Mouse Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0486-FY-S(P)) Inhib Mouse scFv
HPAB-0487-FY-S(P) Human Anti-MET Recombinant Antibody; scFv Fragment (HPAB-0487-FY-S(P)) Inhib Human scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF474 A*02:01/Human Hepatocyte growth factor receptor (YVDPVITSI) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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