This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.
Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.
Figure 3 shows the in vivo effects of 10B3 on body weight.
Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.
Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.
Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2313z | Mouse Anti-MSTN Recombinant Antibody (clone 19F12) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
HPAB-0025-FY | Human Anti-MSTN Recombinant Antibody (HPAB-0025-FY) | FC, SPR, FuncS | Human IgG |
HPAB-0026-FY | Human Anti-MSTN Recombinant Antibody (HPAB-0026-FY) | FuncS | Human IgG |
HPAB-0268CQ | Mouse Anti-MSTN Recombinant Antibody (HPAB-0268CQ) | ELISA, Neut, FuncS | Mouse IgG |
HPAB-0269CQ | Human Anti-MSTN Recombinant Antibody (HPAB-0269CQ) | ELISA, Neut | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-451MZ | Human Anti-MSTN Recombinant Antibody (TAB-451MZ) | FuncS, Inhib | Humanized IgG4 |
TAB-457MZ | Anti-Human MSTN Recombinant Antibody (H0L0) | ELISA, FuncS, Inhib | Humanized antibody |
TAB-457MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (H0L0) | ELISA | Humanized antibody |
TAB-458MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (H1L2) | ELISA | Humanized antibody |
TAB-459MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (H2L2) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-460MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-460MZ-S(P)) | ELISA | Human scFv |
TAB-461MZ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-461MZ-S(P)) | ELISA | Human scFv |
TAB-452MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-452MZ-F(E)) | ELISA | Human Fab |
TAB-453MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-453MZ-F(E)) | ELISA | Human Fab |
TAB-454MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (F1-10) | SDS-PAGE, WB, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0056-WJ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0056-WJ-F(E)) | ELISA, WB | Humanized Fab |
HPAB-0276LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0276LY-F(E)) | ELISA, Neut, in vivo effect | Humanized Fab |
HPAB-0277LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0277LY-F(E)) | ELISA | Humanized Fab |
HPAB-0278LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0278LY-F(E)) | ELISA | Humanized Fab |
HPAB-0279LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0279LY-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP389-YC-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-AP389-YC-S(P)) | ELISA, Neut | Humanized scFv |
HPAB-AP390-YC-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-AP390-YC-S(P)) | ELISA, Neut | Humanized scFv |
HPAB-AP391-YC-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-AP391-YC-S(P)) | ELISA, Neut | Humanized scFv |
HPAB-0583YY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0583YY-S(P)) | ELISA, FuncS | Humanized scFv |
HPAB-0584YY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0584YY-S(P)) | ELISA, FuncS | Humanized scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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