Anti-Human MSTN Recombinant Antibody (10B3) (CAT#: TAB-455MZ)

This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.


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  • Published Data
  • Gene Expression
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Inhib

Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.

Inhib

Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.

FuncS

Figure 3 shows the in vivo effects of 10B3 on body weight.

Figure 3 shows the in vivo effects of 10B3 on body weight.

FuncS

Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.

FuncS

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.

FuncS

Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.

FuncS

Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.

Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.


Specifications

  • Immunogen
  • Mature myostatin
  • Host Species
  • Mouse
  • Specificity
  • Human
  • Clone
  • 10B3
  • Applications
  • FuncS, Inhib
  • Related Disease
  • Muscle atrophy

Applications

  • Application Notes
  • This antibody has been reported for use in Functional Assay, Inhibition.

Target

  • Alternative Names
  • MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 10B3"

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Chimeric Antibody

CAT Product Name Application Type
TAB-456MZ Anti-Human MSTN Recombinant Antibody (10B3C) FuncS, Inhib Chimeric antibody (mouse/human)
TAB-456MZ-S(P) Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) ELISA Chimeric antibody (mouse/human)
TAB-456MZ-F(E) Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) ELISA Chimeric antibody (mouse/human)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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