Anti-Human MSTN Recombinant Antibody (10B3) (CAT#: TAB-455MZ)
This antibody which binds to myostatin can be potentially used in the treatment or prophylaxis of diseases associated with any one or a combination of decreased muscle mass, muscle strength and muscle function.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
Figure 1 shows inhibition of myostatin binding to ActRIIb by 10B3 and 10B3 chimera.
Figure 2 shows the 10B3 and 10B3 chimera inhibition of myostatin-induced activation of cell signalling, resulting in decreased luciferase expression in A204 cells.
Figure 3 shows the in vivo effects of 10B3 on body weight.
Figure 4 shows the ex vivo effects of 10B3 on muscle contractility in EDL, shows tetanic force.
Figure 5 shows 10B3, 10B3C, HOLO and H2L2 inhibition of myostatin- induced activation of cell signalling, resulting in luciferase expression in A204 cells.
Figure 6 shows the effect of 10B3 and control antibody treatment on body weight in C-26 tumour bearing mice from day 0 to day 25.
Figure 7 shows the effect of 10B3 and control antibody treatment in sham operated and tenotomy surgery on mouse tibialis anterior (TA) muscle.
Specifications
- Immunogen
- Mature myostatin
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 10B3
- Applications
- FuncS, Inhib
- Related Disease
- Muscle atrophy
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay, Inhibition.
Target
- Alternative Names
- MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8; GDF-8; growth differentiation factor 8
- Gene ID
- 2660
- UniProt ID
- O14793
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
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