Mouse Anti-TNFRSF8 Recombinant Antibody (clone T408); scFv Fragment

Name: Mouse Anti-TNFRSF8 Recombinant Antibody (clone T408); scFv Fragment
SKU: HPAB-0335-YC-S(P)
Rating: 5 (1 reviews)

CAT#: HPAB-0335-YC-S(P)

Because CD30 is highly expressed on Hodgkin's lymphoma and anaplastic large cell lymphoma, it is a promising target for immunotherapy. The extracellular portion of CD30 is cleaved, releasing a form known as soluble CD30 ("sCD30"), which can reduce the effects of CD30-targeting agents by competitive binding. The antibody binds to the membrane-specific epitopes (Ep7) are located near the middle of the extracellular domain of CD30 that are missing on soluble CD30. Ligands that bind to these epitopes can be used to target cells with intact CD30 without competition from sCD30.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HDLM-2

Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg

Subcellular Location Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg

Subcellular Location Figure 3 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg

Subcellular Location Figure 4 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg

Subcellular Location Figure 5 IF staining of human cell line EFO-21

Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg

Subcellular Location Figure 6 IF staining of human cell line K-562

Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg

Normal Tissue Figure 7 Colon

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg

Normal Tissue Figure 8 Appendix

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

❮

❯

Specifications

Immunogen
pHRm30c, and sCD30 protein

Host Species
Mouse

Type
Mouse scFv

Specificity
Human TNFRSF8

Species Reactivity
Human

Clone
T408

Applications
ELISA, FC, WB

Related Disease
HD

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
CD30; Ki-1; D1S166E

Gene ID
943

UniProt ID
P28908

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for HPAB-0335-YC-S(P). Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-0335-YC-S(P).pdf

MSDS

MSDS - HPAB-0335-YC-S(P).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Clone T408"

CAT
Product Name

See other products for "TNFRSF8"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-144	Anti-Human CD30 Recombinant Antibody (Iratumumab)	ELISA, FC, IP, FuncS, IF, Neut, ICC	IgG1 - kappa

CAT	Product Name	Application	Type
TAB-153	Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153)	Neut, ELISA, IF, IP, FuncS, FC, ICC	Human IgG1, κ

CAT	Product Name	Application
AGTO-G062R	Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G062S	Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap	Cytotoxicity assay, Function study
AGTO-L041E	anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE	Cytotoxicity assay, Functional assay
AGTO-L041R	anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA	Cytotoxicity assay, Functional assay
AGTO-L041S	anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
TAB-635CL	Human Anti-TNFRSF8 Recombinant Antibody (TAB-635CL)	ELISA	Human IgG
TAB-103LC	Anti-Human TNFRSF8 Recombinant Antibody	WB, FC, ELISA	Humanized antibody
TAB-103LC-S(P)	Anti-Human TNFRSF8 Recombinant Antibody scFv Fragment	WB, FC, ELISA	Humanized antibody
TAB-103LC-F(E)	Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment	WB, FC, ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-139LC	Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-139LC-1	Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
BRD-0597MZ	Chicken Anti-TNFRSF8 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-2165CQ	Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1)	FC, Stim, Costim, Block	Hamster IgG1

CAT	Product Name	Application	Type
NEUT-2166CQ	Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F)	Neut, FC	Hamster IgG1, κ

CAT	Product Name	Application	Type
MOR-3617	Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3617AB)	WB, IHC-P	Rabbit IgG
MOR-3618	Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3618AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0329-YC	Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0329-YC)	ELISA, FC, Cyt, FuncS, Inhib	Mouse IgG
HPAB-0330-YC	Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0330-YC)	ELISA, FC, Cyt, FuncS, Inhib	Chimeric (mouse/human) IgG1, κ
HPAB-0331-YC	Mouse Anti-TNFRSF8 Recombinant Antibody (HPAB-0331-YC)	ELISA, FC, Cyt, FuncS, Inhib	Mouse IgG
HPAB-0332-YC	Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0332-YC)	FC, Cyt, FuncS	Human IgG1, κ
HPAB-0333-YC	Human Anti-TNFRSF8 Recombinant Antibody (HPAB-0333-YC)	FC, Cyt, FuncS	Human IgG, κ

CAT	Product Name	Application	Type
HPAB-0329-YC-S(P)	Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0329-YC-S(P))	ELISA, FC, Cyt, FuncS	Mouse scFv
HPAB-0330-YC-S(P)	Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0330-YC-S(P))	ELISA, FC, Cyt, FuncS	Mouse scFv
HPAB-0331-YC-S(P)	Mouse Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0331-YC-S(P))	ELISA, FC, Cyt, FuncS	Mouse scFv
HPAB-0332-YC-S(P)	Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0332-YC-S(P))	FC, Cyt	Human scFv
HPAB-0333-YC-S(P)	Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0333-YC-S(P))	FC, Cyt, FuncS	Human scFv

CAT	Product Name	Application	Type
HPAB-0445-CN-F(E)	Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105); Fab Fragment	WB, ELISA, FC	Mouse Fab
HPAB-0447-CN-F(E)	Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405); Fab Fragment	WB, ELISA	Mouse Fab
HPAB-0325CQ-F(E)	Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0325CQ-F(E))	ELISA, FC, FuncS, Cyt	Humanized Fab
HPAB-0326CQ-F(E)	Mouse Anti-TNFRSF8 Recombinant Antibody (clone Ki-4); Fab Fragment	Inhib, ELISA, FC, IF, IHC	Mouse Fab
HPAB-0459-WJ-F(E)	Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0459-WJ-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
AFC-TAB-144	Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-144)	ELISA, FC, IP, FuncS, IF, Neut	ADCC enhanced antibody
AFC-TAB-153	Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-153)	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0724-XY50	Mouse Anti-TNFRSF8 Agonistic Antibody (VS-0724-XY50)	WB, FC, Agonistic assays, CyTOF®	Mouse IgG2b

CAT	Product Name	Application	Type
VS-0125-FY77	Human Anti-TNFRSF8 (clone Iratumumab) scFv-Fc Chimera	ELISA, FC, IP, FuncS, IF, Neut	Human IgG1, scFv-Fc
VS-0325-FY13	Human Anti-TNFRSF8 scFv-Fc Chimera (VS-0325-FY13)	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY223	CytoStream™ Armenian Hamster Anti-TNFRSF8 Recombinant Antibody (VS-0225-XY223)	FC	Armenian Hamster IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC248	Recombinant Anti-TNFRSF8 Vesicular Antibody, EV Displayed (VS-0425-YC248)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY7385	Anti-TNFRSF8 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC181	Recombinant Anti-TNFRSF8 (Ep2 x Ep7) Biparatopic Antibody, Tandem scFv (Clone T215 x Clone T408)	ELISA, FC, WB	Tandem scFv
VS-0525-YC183	Recombinant Anti-TNFRSF8 (AA 107-153 x AA 282-338) Biparatopic Antibody, Tandem scFv (Clone T105 x Clone T405)	ELISA, WB	Tandem scFv
VS-0525-YC234	Recombinant Anti-TNFRSF8 Biparatopic Antibody, Tandem scFv	ELISA, FC, ICC, IF, IP, Neut	Tandem scFv

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 4 Mouse Anti-HA-Tag Antibody (ZG-0285U) in FC

Mouse Anti-HA-Tag Recombinant Antibody (clone 18B11H6) (CAT# ZG-0285U)
Application: ELISA, WB, IF, FC, IP

Figure 4 Mouse Anti-ACTA2 Antibody (ZG-1036F) in IHC

Mouse Anti-ACTA2 Recombinant Antibody (clone HHF35) (CAT# ZG-1036F)
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB

Figure 5 Human Anti-EBV gB Recombinant Antibody (Clone AMMO5) (PABS-0040) in DB

Human Anti-EBV gB Recombinant Antibody (Clone AMMO5) (CAT# PABS-0040)
Application: ELISA, Neut, FuncS

Figure 3 Human Anti-EBV gB Recombinant Antibody (Clone AMMO3) (PABS-0038) in ELISA

Human Anti-EBV gB Recombinant Antibody (Clone AMMO3) (CAT# PABS-0038)
Application: ELISA, FuncS

Figure 2 Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PABX-098-F(E)) in HPLC

Human Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (PABX-098-F(E)) (CAT# PABX-098-F(E))
Application: WB, ELISA, FuncS

Figure 3 Anti-ANGPT2 Therapeutic Antibody (TAB-769) in ELISA

Anti-ANGPT2 Recombinant Antibody (CAT# TAB-769)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-ERBB2 Recombinant Antibody (Margetuximab) (TAB-761) in SPR

Anti-ERBB2 Recombinant Antibody (Margetuximab) (CAT# TAB-761)
Application: IF, IP, Neut, FuncS, ELISA, FC, WB

Figure 5 Anti-Human folate receptor 1 Antibody (TAB-113) in SEC-HPLC

Anti-Human folate receptor 1 Recombinant Antibody (TAB-113) (CAT# TAB-113)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 6 Anti-Human VEGF Recombinant Antibody (TAB-011) in ELISA

Anti-Human VEGF Recombinant Antibody (Bevacizumab) (CAT# TAB-011)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Figure 1 Anti-Human ENG Recombinant Antibody (TAB-232CL) in SDS-PAGE

Anti-Human ENG Recombinant Antibody (TAB-232CL) (CAT# TAB-232CL)
Application:

Figure 2 Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody (PABW-092) in HPLC

Recombinant Mouse Anti-N. meningitidis PorA (P1.2) Antibody (MN16C13F4) (CAT# PABW-092)
Application: ELISA

Figure 2 Human Anti-FGFR3 Recombinant Antibody (PABL-474) in WB

Human Anti-FGFR3 Recombinant Antibody (clone R3Mab) (CAT# PABL-474)
Application: ELISA

Figure 5 Human Anti-IL13 Recombinant Antibody (clone CNTO607) (PABW-170) in SEC-HPLC

Human Anti-IL13 Recombinant Antibody (clone CNTO607) (CAT# PABW-170)
Application: ELISA, WB, Neut

Figure 2 Human Anti-CD3 Recombinant Antibody (TAB-0416CL-S(P)) in WB

Mouse Anti-CD3 Recombinant Antibody scFv Fragment (TAB-0416CL-S(P)) (CAT# TAB-0416CL-S(P))
Application: IB, ELISA, FC, FuncS

Figure 3 Anti-GPC3 Antibody (TAB-263CQ) in Dot Blot

Anti-Human GPC3 Recombinant Antibody (TAB-263CQ) (CAT# TAB-263CQ)
Application: ELISA, Inhib, IHC

Figure 4 Anti-MUC1 Recombinant Antibody (TAB-439MZ) in WB

Anti-Human MUC1 Recombinant Antibody (1B2) (CAT# TAB-439MZ)
Application: FC

Figure 3 Anti-CD27 Recombinant Antibody (MOB-096LC) in DB

Human Anti-CD27 Recombinant Antibody (MOB-096LC) (CAT# MOB-096LC)
Application: ELISA, FuncS, WB

Figure 2 Recombinant Mouse Anti-HBV preS1/preS2 Antibody (EPAF-0331CQ) in HPLC

Recombinant Mouse Anti-HBV preS1/preS2 Antibody (mAb 18/7) (CAT# EPAF-0331CQ)
Application: Neut, WB

Figure 3 Anti-MAPT Recombinant Antibody (NS-090CN) in ELISA

Mouse Anti-MAPT Recombinant Antibody (NS-090CN) (CAT# NS-090CN)
Application: WB, ELISA, IHC, IP, SPR, FuncS

Figure 2 Mouse Anti-Cs Recombinant Antibody (FAMAB-0077YC) in ELISA

Mouse Anti-Cs Recombinant Antibody (clone R45-45-11) (CAT# FAMAB-0077YC)
Application: ELISA