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    anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap (CAT#: AGTO-L041S)

    This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lymphoma cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of lymphoma.

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    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line HDLM-2
    Figure 1 IF staining of human cell line HDLM-2
    (Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg
    Figure 2 IHC staining of human testis
    Figure 2 IHC staining of human testis
    (Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg
    Figure 3 IHC staining of human tonsil
    Figure 3 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg
    Figure 4 IHC staining of human tonsil
    Figure 4 IHC staining of human tonsil
    (Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg
    Figure 5 IF staining of human cell line EFO-21
    Figure 5 IF staining of human cell line EFO-21
    (Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg
    Figure 6 IF staining of human cell line K-562
    Figure 6 IF staining of human cell line K-562
    (Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg
    Normal Tissue
    Figure 7 Colon
    Figure 7 Colon
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg
    Figure 8 Appendix
    Figure 8 Appendix
    (Glandular cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    Figure 9 RNA cell line category: Cell line enriched (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Clone
    • Ber-H2
    • Molecule Class
    • L kappa; IgG1-Sap
    • Toxin Description
    • Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • Lymphoma

    Target

    • Alternative Names
    • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30; Lymphoma; saporin; saporin-6; saporin-S6; SAP

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

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