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  3. anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap

anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap (AGTO-L041S)

This immunotoxin was achieved by conjugating/fusing the Anti-TNFRSF8 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to lymphoma cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of lymphoma.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
Ber-H2
Molecule Class
L kappa; IgG1-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Lymphoma
Target
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor
Entrez Gene ID
943
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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Recombinant Mouse Anti-TNFRSF8 Antibody (Ki-4)    ( HPAB-0326CQ )
Anti-CD30 (cAC10)-mc-vc-MMAE ADC    ( ADC-041LCT )
Recombinant Mouse Anti-TNFRSF8 Antibody (T105)    ( HPAB-0445-CN )
Anti-Human TNFRSF8 Therapeutic Antibody scFv Fragment    ( TAB-103LC-S(P) )
Chicken Anti-TNFRSF8 Polyclonal IgY    ( BRD-0597MZ )
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