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Mouse Anti-TP53 Recombinant Antibody (clone 421); scFv Fragment (CAT#: HPAB-0004-YC-S(P))

The p53 protein is the product of a tumor suppressor gene that functions to arrest the growth of mutated or aberrant cells. The p53 protein is a transcription factor that binds specifically to a consensus site present in the regulatory sequences of p53-dependent genes. Thus the wild-type p53 molecule, and not only the mutated p53 molecule, can serve as a target for a potentially therapeutic anti-tumor immune response.


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  • Endotoxin:
  • Purity:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39239/651_G2_2_selected.jpg
Figure 2 IF staining of human cell line A549
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63532/1113_C11_2_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & mitochondria.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79965/1999_E7_4_selected.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39238/656_H2_1_red_green.jpg
Normal Tissue
Figure 5 Oral mucosa
Figure 5 Oral mucosa
(Squamous epithelial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2973/6986_A_8_1.jpg
Figure 6 Colon
Figure 6 Colon
(Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2973/6986_A_9_3.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000141510-TP53
Figure 7 RNA cell line category: Low cell line specificity
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000141510-TP53

Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse scFv
  • Specificity
  • Human TP53
  • Species Reactivity
  • Human, Mouse
  • Clone
  • 421
  • Applications
  • IP, ELISA
  • Related Disease
  • Lung carcinoma metastasis

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • TP53; Tumor protein p53; P53; BCC7; LFS1; TRP53

Related Resources

  • Related Diseases

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 421"

See other products for "TP53"

Single-domain Antibody

CAT Product Name Application Type
PNBL-072 Recombinant Anti-p53 VHH Single Domain Antibody (Nb139) Inhib, IP, WB, ELISA, FuncS Llama VHH
HPAB-0746-YJ-VHH Camelid Anti-TP53 Recombinant Single Domain Antibody (CBP71YJ) ELISA Camelid VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3644 Rabbit Anti-TP53 Recombinant Antibody (clone DS3644AB) IHC-P Rabbit IgG
MOR-4524 Rabbit Anti-TP53 Recombinant Antibody (clone TH32DS) WB, IF, ICC Rabbit IgG
MOR-4698 Rabbit Anti-TP53 Recombinant Antibody (clone TH212DS) WB, IF, ICC, FC, ChIP, FRET Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC2368 PE-A*24:02/Human TP53 (KYPENFFLL) MHC Tetramer FCM
MHC-LC3065 PE-A*02:01/Human TP53 (CQLAKTCPV) MHC Tetramer FCM
MHC-LC3066 PE-A*02:02/Human TP53 (CQLAKTCPV) MHC Tetramer FCM
MHC-LC3067 PE-A*02:03/Human TP53 (CQLAKTCPV) MHC Tetramer FCM
MHC-LC3068 PE-A*02:06/Human TP53 (CQLAKTCPV) MHC Tetramer FCM

Model Organism Antibody

CAT Product Name Application Type
MD-ZBF-YC001 Recombinant Mouse Anti-Zebrafish tp53 Antibody (ZFp53-1.1) WB, ICC Mouse antibody
MD-ZBF-YC002 Recombinant Mouse Anti-Zebrafish tp53 Antibody (ZFp53-2.1) WB, ICC, IHC Mouse antibody
MD-ZBF-YC003 Recombinant Mouse Anti-Zebrafish tp53 Antibody (ZFp53-3.1) WB, ICC Mouse antibody
MD-ZBF-YC004 Recombinant Mouse Anti-Zebrafish tp53 Antibody (ZFp53-4.1) WB, ICC Mouse antibody
MD-ZBF-YC005 Recombinant Mouse Anti-Zebrafish tp53 Antibody (ZFp53-5.1) WB, ICC, IHC Mouse antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0001-YC-S(P) Mouse Anti-TP53 Recombinant Antibody (clone 70237-85); scFv Fragment IHC, WB, ELISA Mouse scFv
HPAB-0002-YC-S(P) Mouse Anti-TP53 Recombinant Antibody (clone 240); scFv Fragment IP, ELISA Mouse scFv
HPAB-M0287-YC-S(P) Mouse Anti-TP53 Recombinant Antibody (clone 6C4); scFv Fragment ELISA Mouse scFv
HPAB-0662-YJ-S(P) Mouse Anti-TP53 Recombinant Antibody (clone Ab421); scFv Fragment ELISA Mouse scFv
HPAB-1568WJ-S(P) Mouse Anti-TP53 Recombinant Antibody; scFv Fragment (clone 11D3) ELISA, WB Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0001-YC-F(E) Mouse Anti-TP53 Recombinant Antibody (clone 70237-85); Fab Fragment IHC, WB, ELISA Mouse Fab
HPAB-0002-YC-F(E) Mouse Anti-TP53 Recombinant Antibody (clone 240); Fab Fragment IP, ELISA Mouse Fab
HPAB-0003-YC-F(E) Mouse Anti-TP53 Recombinant Antibody (clone 246); Fab Fragment IP, ELISA Mouse Fab
HPAB-0004-YC-F(E) Mouse Anti-TP53 Recombinant Antibody (clone 421); Fab Fragment IP, ELISA Mouse Fab
HPAB-0005-YC-F(E) Mouse Anti-TP53 Recombinant Antibody (clone ME1); Fab Fragment ELISA Mouse Fab

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0633CQ Mouse Anti-TP53 Recombinant Antibody (clone p53-11) WB Mouse IgG

Recombinant Antibody

CAT Product Name Application Type
MRO-2351-CN Rabbit Anti-TP53 Recombinant Antibody (clone CBACN-640) WB Rabbit IgG
MRO-2352-CN Rabbit Anti-TP53 Recombinant Antibody (clone CBACN-641) WB Rabbit IgG
HPAB-M0287-YC Mouse Anti-TP53 Recombinant Antibody (clone 6C4) ELISA Mouse IgG1
HPAB-0662-YJ Mouse Anti-TP53 Recombinant Antibody (clone Ab421) ELISA Mouse IgG
ZG-0344C Mouse Anti-TP53 Recombinant Antibody (ZG-0344C) WB Mouse IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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