Anti-fibronectin (clone F8)-DM1-SH ADC (CAT#: ADC-062LZY)

This ADC product is composed of an anti-fibronectin antibody (clone F8) conjugated via linker to DM1-SH (F8-DM1-SH). It has demonstrated a response in murine F9 teratocarcinomas treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • F8 Antibody in IgG format
  • Clone
  • F8
  • Antibody Isotype
  • IgG1
  • Antibody Conjugation
  • the mutation of heavy chain hinge cysteine residues into serine allows a site-specific drug coupling at the C-terminal cysteine residue of the
    light chain.
  • Linker
  • disulfide linkers
  • Linker Class/Description
  • Class: Chemically cleavable Linker-Disulfide Linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1-SH(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine-SH)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor;

Related Resources

  • Related Diseases

Downloads

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See other products for "Clone F8"

See other products for "FN1"

Human Antibody

CAT Product Name Application Type
TAB-193 Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) IF, IP, Neut, FuncS, ELISA, FC, ICC [(scFv - heavy - kappa) - IGHE - CH4]2
TAB-001CQ Anti-Human FN1 Recombinant Antibody (MOR03255) ELISA, Block, IHC Human antibody
TAB-002CQ Anti-Human FN1 Recombinant Antibody (ME-4C) ELISA, IHC Human antibody
TAB-071WM Anti-Human FN1 Recombinant Antibody (CGS-1) ELISA, WB Human Antibody
TAB-071WM-F(E) Anti-Human FN1 Recombinant Antibody Fab Fragment (CGS-1) ELISA, WB Human Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) ELISA, In vivo imaging Camelid VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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