Anti-fibronectin (clone F8)-DM1-SH ADC (CAT#: ADC-062LZY)

• Antibody Overview
• F8 Antibody in IgG format

• Clone
• F8

• Antibody Isotype
• IgG1

• Antibody Conjugation
• the mutation of heavy chain hinge cysteine residues into serine allows a site-specific drug coupling at the C-terminal cysteine residue of the
  light chain.

• Linker
• disulfide linkers

• Linker Class/Description
• Class: Chemically cleavable Linker-Disulfide Linker
  Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.

• Drug
• DM1-SH(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine-SH)

• Drug Class/Description
• Class: Maytansinoid
  Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
  macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

• Introduction
• This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

• Alternative Names
• FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor;

• Gene ID
• 2335

• UniProt ID
• P02751

• ADC-137LZY
• Anti-Fibronectin (clone F8)-CemCH2-SH ADC

• ADC-063LZY
• Anti-fibronectin (clone F8)-DM1-SH ADC

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