Anti-Fibronectin (clone F8)-CemCH2-SH ADC
CAT#: ADC-137LZY
This ADC product is composed of an anti-Fibronectin antibody (clone F8) conjugated via linker to CemCH2-SH (anti-Fibronectin SIP(F8)-CemCH2-SH). It has demonstrated a response in tumors treatment by a MOA (Mechanism of Action) of inhibiting microtubule assembly.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1
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Specifications
- Antibody Overview
- F8 Antibody in small immune protein (SIP) format
- Clone
- F8
- Linker
- disulfide linker
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- CemCH2-SH
- Drug Class/Description
- Class: Cemadotin
Description: Cemadotin is a synthetic analogue of dolastatin 15 with potent antiproliferative and preclinical antitumor activity.The dolastatins are a class of naturally occurring cytotoxic peptides which function by inhibiting microtubule assembly and tubulin polymerization.
Target
- Introduction
- This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
- Alternative Names
- FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor;
- Gene ID
- 2335
- UniProt ID
- P02751
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Datasheet
MSDS
COA
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See other products for "Clone F8"
- CAT
- Product Name
See other products for "FN1"
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|---|---|---|---|
| TAB-001CQ | Anti-Human FN1 Recombinant Antibody (MOR03255) | ELISA, Block, IHC | Human antibody |
| TAB-001CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
| TAB-002CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (ME-4C) | ELISA, IHC | Human antibody |
| TAB-003CQ-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (1C5) | ELISA, WB | Human antibody |
| TAB-004CQ-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (TAB-004CQ-S(P)) | ELISA, IHC, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
| NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
| HPAB-1111-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1111-FY-S(P)) | IHC | Human scFv |
| HPAB-1112-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1112-FY-S(P)) | IHC | Human scFv |
| HPAB-S0037-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); Fab Fragment | ELISA, IB, IHC | Human Fab |
| HPAB-S0038-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone L19); Fab Fragment | ELISA, IF, IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1705-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02610); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1706-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02611); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-1707-FY-F(E) | Mouse Anti-FN1 Recombinant Antibody (clone MOR02613); scFv Fragment | ELISA, IHC | Mouse scFv |
| HPAB-S0037-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment | ELISA, IB, IHC | Human scFv |
| HPAB-S0038-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment | ELISA, IF, IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0037-YC | Human Anti-FN1 Recombinant Antibody (clone CGS-2) | ELISA, IB, IHC | Human IgG |
| HPAB-S0038-YC | Human Anti-FN1 Recombinant Antibody (clone L19) | ELISA, IF, IHC | Human IgG |
| ZG-0661F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0661F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
| ZG-0662F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0662F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
| ZG-0663F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0663F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NBD-0040-YJ-VHH) | ELISA, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY105 | AbPlus™ Anti-FN1 Magnetic Beads (HFN7.1) | IP, Protein Purification | |
| VS-0724-YC853 | AbPlus™ Anti-FN1 Magnetic Beads (VS-0724-YC853) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY204 | Mouse Anti-NHP FN1 Recombinant Antibody (clone C6F10) | WB, IHC, IF, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY108 | Human Anti-FN1 (clone L19) scFv-Fc Chimera | IHC, ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2593 | Anti-FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2594 | Anti-Rat FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2595 | Anti-Mouse FN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC87 | Recombinant Anti-FN1 ED-B (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone CGS-2 x Clone CGS-1) | ELISA | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC121 | Recombinant Anti-FN1 Eliminating Antibody, pH-Sensitive (VS-0625-YC121) | Antigen-Sweeping In Vivo. | Human IgG1 kappa |
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