Anti-Fibronectin (clone F8)-CemCH2-SH ADC
CAT#: ADC-137LZY
This ADC product is composed of an anti-Fibronectin antibody (clone F8) conjugated via linker to CemCH2-SH (anti-Fibronectin SIP(F8)-CemCH2-SH). It has demonstrated a response in tumors treatment by a MOA (Mechanism of Action) of inhibiting microtubule assembly.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_9_4.jpg
Normal Tissue
Figure 4 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_5_6.jpg
Normal Tissue
Figure 5 Placenta
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_1_7.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/126/2077_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (ASC TERT1, HSkMC, hTERT-HME1, hTERT-RPE1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000115414-FN1
❮
❯
Specifications
- Antibody Overview
- F8 Antibody in small immune protein (SIP) format
- Clone
- F8
- Linker
- disulfide linker
- Linker Class/Description
- Class: Chemically cleavable Linker-Disulfide Linker
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- CemCH2-SH
- Drug Class/Description
- Class: Cemadotin
Description: Cemadotin is a synthetic analogue of dolastatin 15 with potent antiproliferative and preclinical antitumor activity.The dolastatins are a class of naturally occurring cytotoxic peptides which function by inhibiting microtubule assembly and tubulin polymerization.
Target
- Introduction
- This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
- Alternative Names
- FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor;
- Gene ID
- 2335
- UniProt ID
- P02751
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-137LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
AGE-RAGE Signaling Pathway in Diabetic Complications
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone F8"
- CAT
- Product Name
See other products for "FN1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193 | Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | [(scFv - heavy - kappa) - IGHE - CH4]2 |
| TAB-001CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
| TAB-002CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (ME-4C) | ELISA, IHC | Human antibody |
| TAB-003CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (1C5) | ELISA, WB | Human antibody |
| TAB-004CQ-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (TAB-004CQ-F(E)) | ELISA, IHC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
| NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0193-CN-F(E) | Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0193-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0194-CN-F(E) | Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0194-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
| HPAB-0195-CN-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0195-CN-F(E)) | ELISA, FC, IHC | Humanized Fab |
| HPAB-0196-CN-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0196-CN-F(E)) | ELISA, FC, IHC | Humanized Fab |
| HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0105-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone ME4C); scFv Fragment | ELISA, IHC | Human scFv |
| HPAB-1110-FY-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-1110-FY-F(E)) | IHC | Human Fab |
| HPAB-1111-FY-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-1111-FY-F(E)) | IHC | Human Fab |
| HPAB-1112-FY-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-1112-FY-F(E)) | IHC | Human Fab |
| HPAB-1113-FY-F(E) | Human Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-1113-FY-F(E)) | IHC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1110-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1110-FY) | IHC | Human IgG |
| HPAB-1111-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1111-FY) | IHC | Human IgG |
| HPAB-1112-FY | Human Anti-FN1 Recombinant Antibody (HPAB-1112-FY) | IHC | Human IgG |
| ZG-0035C | Mouse Anti-FN1 Recombinant Antibody (clone M9) | WB, IHC-P, IF, ICC | Mouse IgG |
| VS3-WK1282 | Mouse Anti-FN1 Recombinant Antibody (VS3-WK1282) | ELISA, WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NBD-0040-YJ-VHH) | ELISA, In vivo imaging | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY105 | AbPlus™ Anti-FN1 Magnetic Beads (HFN7.1) | IP, Protein Purification | |
| VS-0724-YC853 | AbPlus™ Anti-FN1 Magnetic Beads (VS-0724-YC853) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY204 | Mouse Anti-NHP FN1 Recombinant Antibody (clone C6F10) | WB, IHC, IF, IP | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY108 | Human Anti-FN1 (clone L19) scFv-Fc Chimera | IHC, ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2593 | Anti-FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2594 | Anti-Rat FN1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2595 | Anti-Mouse FN1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC87 | Recombinant Anti-FN1 ED-B (N-terminus x C-terminus) Biparatopic Antibody, Tandem scFv (Clone CGS-2 x Clone CGS-1) | ELISA | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
-2.png)
Application: IB, ELISA, FC, FuncS
-YJ-3.jpg)
Application: ELISA
Application: Neut, Inhib, FC, ELISA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, WB, FC
Application: ELISA, IHC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
